鼠种植性胃肿瘤模型的制作方法及抗癌药物的治疗作用  

Development of Implanted Gastric Tumor Model in Mice and Therapeutic Effects of Anticarcinogen

作　　者：陶凯雄[1] 田源[1] 陈道达[1] 

机构地区：[1]同济医科大学附属协和医院外科,武汉430022

出　　处：《同济医科大学学报》2000年第3期229-231,共3页Acta Universitatis Medicinae Tongji

基　　金：国家"九五"重点医学科技攻关专题资助项目!(No.96 9060116)

摘　　要：利用 Walker- 2 5 6细胞株可成功地复制出种植性胃肿瘤模型 ,病理组织学证实该肿瘤与皮下实体瘤同源 ;皮下注射阿霉素可明显改善荷瘤鼠的生存质量 ,延长其生存时间 ,抑制肿瘤的生长 (P<0 . 0 1) 。The models of implanted gastric tumor in mice were duplicated successfully by using malignant tumor cell line Walker 256. Their histopathologic features were homologous to those of the subcutaneous implanted tumor of Walker 256 cells in mice. Subcutaneous injection of adriamycin could obviously improve the life qualities of the mice bearing implanted gastric tumor, prolong the survival time and inhibit the tumor growth ( P <0.01), suggesting that the model of implanted gastric tumor in mice was an ideal one for the experimental study in gastric cancer.

关 键 词：种植性胃肿瘤 阿霉素 动物模型 抗癌药 

分 类 号：R735.02[医药卫生—肿瘤] R979.1[医药卫生—临床医学]