多药耐受相关蛋白在膀胱肿瘤组织中表达的临床意义  

The Clinical Implication of MRP Expression in Human Bladder Tumors

作　　者：章小平[1] 鲁功成[1] 杨红枚 

机构地区：[1]同济医科大学附属协和医院外科,武汉430022 [2]武汉大学生命科学院病毒与分子生物学系,武汉430072

出　　处：《同济医科大学学报》2000年第3期236-238,共3页Acta Universitatis Medicinae Tongji

基　　金：国家自然科学基金资助项目!(No.39670723)

摘　　要：应用免疫组织化学 SABC方法检测了 10 3例膀胱肿瘤和 10例正常膀胱粘膜的多药耐受相关蛋白 (MRP)表达。结果发现 :MRP表达在膀胱恶性肿瘤与正常膀胱粘膜、单发与多发、初发与复发、浅表性肿瘤 (p Ta- p T1)与浸润性肿瘤 (p T2及以上 )之间的差异都分别具有统计学意义 (P<0 .0 5 )。良性肿瘤和恶性肿瘤之间 MRP差异无显著意义。随着移行细胞癌 (TCC)分级的升高 ,虽然 MRP表达阳性率也升高 ,但各级之间差异并无显著意义。膀胱肿瘤 MRP表达和肿瘤术后分期、复发、多发之间关系密切 。Multidrug resistant associated protein (MRP) expression in 103 bladder tumor samples and 10 normal bladder mucosa samples were detected by using immunohistochemical streptavidin biotin enzyme complex (SABC) method. The results showed that the difference in MRP expression between malignant tumor and normal mucosa, reoccurrence and initial occurrence, single tumor and multifocal tumors, superficial tumors (pTa pT1) and invasive tumors (above pT1) was statistically significant ( P <0 05), respectively. MRP expression in transitional cell carcinoma (TCC) was increased with the increase of the classes, but no significant difference in MRP expression among various classes was found. It was concluded that MRP expression had a close relation with postoperative stage, reoccurrence and multifocal tumors of bladder tumor and could be used as a prognosis index of bladder tumors.

关 键 词：多药耐受性 多药耐受相关蛋白 膀胱肿瘤 

分 类 号：R737.14[医药卫生—肿瘤]