拓扑异构酶Ⅱ在胃癌中的表达  

Significance of Topoisomerase Ⅱ in Primary Gastric Carcinomas

作　　者：张声[1] 陈林莺[1] 李莉[1] 曾赛凡[1] 陈余朋[1] 

机构地区：[1]福建医科大学附属第一医院病理科,福州350005

出　　处：《福建医科大学学报》2000年第2期132-134,共3页Journal of Fujian Medical University

基　　金：福建省卫生厅科研基金!资助项目 ( 9710 9);福建省教委科研基金!资助项目 ( JA9810 3 )

摘　　要：目的　探讨胃癌拓扑异构酶 与 ki- 6 7表达的相关性。　方法　免疫组织化学方法研究 2 76例原发性胃癌拓扑异构酶 和 ki- 6 7标记指数的变化关系。　结果　弥漫型胃癌拓扑异构酶 和 ki- 6 7的标记指数明显高于肠型胃癌 ,拓扑异构酶 标记指数与 ki- 6 7标记指数呈明显的正相关 (r=0 .5 334 ,P<0 .0 5 ) ,但 ki- 6 7标记指数明显高于拓扑异构酶 的标记指数。　结论　拓扑异构酶 标记指数除可作为肿瘤患者抗药性指标外 ,还可作为肿瘤细胞增殖指数的指标 ,拓扑异构酶Objective\ Purpose to study the relationship between label index of topoisomerase Ⅱ and ki\|67.\ Methods\ By using immunohistochemical method, the significance of the expression of topoisomerase Ⅱ and ki\|67 were investigated in the primary gastric carcinomas.\ Results\ The label index of topoisomerase Ⅱ and ki\|67 in diffuse\|type carcinomas were higher than those in intestinal\|type carcinomas.\ There was significant correlation between the label index of topoisomerase Ⅱ and ki\|67(r=0 5334,P<0 05), but the label index of ki\|67 was higher than those of topoisomerase Ⅱ. \ Conclusion\ These findings suggest that topoisomerase Ⅱ not only serve as the index of the multidrug resistance, but also as the index of cellular proliferation.\ The expressive contents of topoisomerase Ⅱ is associated with malignant transformation.\;

关 键 词：胃肿瘤 DNA拓扑异构酶 KI-67抗原 免疫组织化学 

分 类 号：R735.2[医药卫生—肿瘤]