中国汉族人群rs1229984多态性与头颈癌发病风险的关联研究  

Investigation of correlation between polymorphism of rs1229984 and head-and-neck cancer risk in a Chinese Han population

作　　者：袁志瑶[1] 袁华[1] 朱龙彪[1] 沈铭[1] 李俊[1] 陈宁[1] 

机构地区：[1]南京医科大学口腔医学研究所.附属口腔医院口腔颌面外科,江苏南京210029

出　　处：《口腔生物医学》2012年第4期173-177,共5页Oral Biomedicine

基　　金：国家重点基础研究发展计划(973计划)(2012CB966902);江苏省自然科学基金(BK2011764);江苏高校优势学科建设工程资助项目

摘　　要：目的:研究寻找与中国汉族人群头颈癌遗传易感性相关的多态位点。方法:采用病例-对照的研究设计,运用TaqMan基因分型方法,在397例新发头颈癌患者和900例性别、年龄相匹配的对照中分析了5个多态位点(rs1494961、rs1229984、rs1789924、rs971074、rs4767364)的遗传变异与中国汉族人群头颈癌易感性的关系。结果:rs1229984(A>G)的遗传变异能够显著影响头颈癌的发病风险。携带rs1229984 AG/GG基因型者罹患头颈癌的风险较携带AA基因型者增加34%(调整OR=1.34,95%CI=1.05～1.71)。本研究未发现其余4个位点多态性与头颈癌之间存在显著性相关。结论:染色体4q23区域的rs1229984多态性与中国汉族人群头颈癌的易感性有关。Objective：To investigate the single nueleotide polymorphisms with significant association with the head and neck cancer （HNC） risk in a Chinese Han population. Methods： We genotyped five variants （ rs1494961, rs1229984, rs1789924, rs971074 and rs4767364） in a case-control study with 397 HNC cases and 900 controls who matched in age and gender, using the TaqMan genotyping. Results：We found that rs1229984 （A 〉 G） significantly increased the risk of HNC ,and people who had rs1229984 AC/GG genotype was 34% higher than those who carry AA genotype [ adjusted odds ratio （OR） = 1.34,95% confidence interval （CI） = 1.05-1. 71 ]. By contrast, no significant association was observed between the other four single nueleotide polymorphisms （SNPs） and HNC risk. Conelusions：Polymorphism of rs1229984 at 4q23 is associated with HNC susceptibility in a Chinese population.

关 键 词：单核苷酸多态性 头颈癌 易感性 

分 类 号：R739.8[医药卫生—肿瘤]