老年人肾脏转化生长因子β_1的表达  

Expression of transforming growth factor β_1 in the aged kidneys

作　　者：赵海潞[1] 牟善初[1] 李红芬[2] 王淑琴[2] 张晓英[1] 李维华[2] 余霞君[1] 张笑明[2] 游联璧[2] Critchley JAJH 

机构地区：[1]解放军总医院老年心肾科,北京市100853 [2]解放军总医院病理科,北京市100853 [3]香港中文大学医学院内科及药物治疗系

出　　处：《中华老年医学杂志》2000年第3期194-196,共3页Chinese Journal of Geriatrics

摘　　要：目的　探讨转化生长因子 (transform ing growth factor,TGF) β1 在肾脏老化过程中的作用。　方法　应用免疫组织化学技术 ,观察 2 4例肾功能正常的老年尸体肾脏间质 TGF- β1 的表达情况。　结果　肾间质中肌纤维母细胞、单核吞噬细胞、淋巴细胞以及远曲小管和集合小管上皮细胞、肾小球系膜细胞和 Bowm an囊上皮细胞、血管平滑肌细胞和内皮细胞均有 TGF-β1 表达。　结论　 TGF-β1 是肾脏老化过程的重要生长因子。Objective To study the role of transforming growth factor (TGF) β 1 in the pathogenesis of glomerulosclerosis, arteriosclerosis and interstitial fibrosis of human aged kidney. Methods Immunohistochemical technique was employed to demonstrate TGF β 1 positive cells in postmortem kidneys of 24 elderly individuals with normal renal function. Results It was found that cells positive for TGF β 1 were the interstitial myofibroblasts, macrophages, lymphocytes, epithelia of distal convoluted ducts and collecting ducts, mesangial cells in the glomeruli and epithelia of Bowman's capsule, smooth muscle cells and endothelial cells of the arteries and arterioles. Conclusions TGF β 1 is an important autocrine and paracrine cytokine in the pathogenesis of glomerulosclerosis, arteriosclerosis and interstitial fibrosis of human aged kidney.

关 键 词：转化生长因子Β 肾脏 免疫组化技术 老年人 

分 类 号：R364[医药卫生—病理学]