探讨^(18)F-FDG PET/CT显像在肺癌骨转移中的诊断价值  

Value of 18F-FDG PET/CT Imaging in Diagnosis of Bone Metastases in Patients with Lung Cancer

作　　者：李勇涛[1] 罗顺祥[2] 陈伯勋[1] 

机构地区：[1]湖北省天门市第一人民医院信息科,431700 [2]湖北省天门市第一人民医院肿瘤科,431700

出　　处：《中华全科医学》2013年第1期133-134,共2页Chinese Journal of General Practice

摘　　要：目的探讨18F-FDG PET/CT显像在诊断肺癌骨转移中的应用价值。方法对67例确诊的肺癌患者分别采用CT诊断、MRI诊断、99Tcm-MDP SPECT和18F-FDG PET/CT显像诊断检查是否发生骨转移,对各法诊断所得数据录入SPSS 17.0进行ROC曲线分析,以肺癌骨转移的诊断灵敏度、误诊率和漏诊率为衡量指标进行统计学分析。结果与CT、MRI和99Tcm-MDP SPECT误诊率比较,18F-FDG PET/CT误诊率显著降低(P<0.05);与CT和MRI漏诊率比较,18F-FDG PET/CT漏诊率显著降低(P<0.05)。表明,18F-FDG PET/CT显像对肺癌骨转移的诊断灵敏度与其他方法无显著性差异、误诊率显著降低、漏诊率明显低于CT和MRI。经过ROC分析,CT、MRI、99Tcm-MDP SPECT、18F-FDG PET/CTROC的曲线均位于机会线之上,18F-FDG PET/CTROC与其他方法曲线下面积相比,差异有统计学意义(P<0.05)。结论18F-FDG PET/CT是一种非侵入性、安全的显像方法,在肺癌及其骨转移灶的诊断和探测上具有较高的特异性和敏感性,值得临床推广应用。Objective To investigate the value of ^18F-FDG PET/CT imaging in the diagnosis of bone metastasis in patients with lung cancer. Methods All 67 cases of diagnosed lung cancer patients were checked by CT, MRI, is F-FDG PET/CT imaging and 99Tcm-MDP SPE/CT imaging, respectively. The diagnostic sensitivity for lung cancer bone metastasis, rate of misdiagnosis and missed diagnosis were statistically analyzed. Results The misdiagnosis rate of lung cancer bone metastasis by ^18F-FDG PET/CT was lower than those by CT, MRI and 99Tcm-MDP（P 〈 0.05 ） ; The missed diagnosis rate of lung cancer bone metastasis by ^18F- FDG PET/CT was lower as compare to CT and MRI （P 〈 0.05 ） ;but the difference in diagnostic sensitivity was not significance a- mong those methods （ P 〉 0.05 ）. ROC curve analysis showed that the difference among those methods was significance （ P 〈 0.05 ）. Conclusion ^18 F-FDG PET/CT is a non-invasive, safe imaging method with high specificity and sensitivity in the diagno- sis and detection of lung cancer and bone metastases. It is worthy of clinical application.

关 键 词：肺癌 骨转移 诊断价值 

分 类 号：R734.2[医药卫生—肿瘤] R817[医药卫生—临床医学]