A型肉毒毒素治疗眼睑及面肌痉挛的临床研究  

The efficacy of using Botox-A in the treatment of blepharospasm and hemifacial spasm

作　　者：曾莉[1] 

机构地区：[1]乐山市人民医院眼科,614000

出　　处：《中国斜视与小儿眼科杂志》2012年第4期151-153,156,共4页Chinese Journal of Strabismus & Pediatric Ophthalmology

摘　　要：目的观察A型肉毒毒素治疗眼睑及面肌痉挛的效果。方法选择38例中度、重度眼睑及面肌痉挛患者,应用A型肉毒毒素局部注射治疗。结果随访6个月~3年,其中30例患者症状完全缓解;7例明显缓解,1例无效。37例患者均在注射后3~4个月复发。复发的37例,28例选择重复注射,所有注射A型肉毒毒素的患者均未出现全身副作用,但注射后20例患者(55.6%)出现不同程度的干眼,角膜点状染色。结论 A型肉毒毒素局部注射治疗中、重度眼睑及面肌痉挛安全、有效。但应注意在注射前后检查眼表情况,注射后常规使用人工泪液。Objective To observe the efficacy of using Botox-A in the treatment of bl^pharospasm （BS） and hemifacial spasm （HFS）. Methods A total of 38 patients with medium and severe BS and HFS whose history lasted more than 6 months were managed with a local injection of Botox-A. Results Followed up 6 months 3 years, 30 cases had a complete remission of symptoms 7 patients presented with obvious relieved spasm and the conditions of 1 patients remained unchanged. 37 cases recurred 3-4 months post injection,28 cases received injection again. No systemic toxic or side effects Were found in all patients ,but 20 cases （55.6%） have dry eyes and corneal epithelial punctate defects. Conclusions BTA local injection is a safe, effective and reliable treatment for patients with BS and HFS. But it is important to examimed the ocular surface and applied artificial tears.

关 键 词：眼睑痉挛 面肌痉挛A型肉毒毒素 干眼 

分 类 号：R746[医药卫生—神经病学与精神病学] R777.1[医药卫生—临床医学]