The regulation of myoblast plasticity and its mechanism  

作　　者：Peng ZHANG Xiao-ping CHEN 

机构地区：[1]State Key Laboratory of Space Medicine Fundamentals and Application,China Astronaut Research and Training Center

出　　处：《中国应用生理学杂志》2012年第6期524-531,共8页Chinese Journal of Applied Physiology

基　　金：supported by grants from National Basic Research Program of China(2011CB711000);Natural Sciences Foundation of China(31171144;81272177);State Key Laboratory Grant of Space Medicine Fundamentals and Application(SM-FA09A01)

摘　　要：The development of skeletal muscle is a highly regulated,multi-step process in which pluripotent mesodermal cells give rise to myoblasts that subsequently withdraw from the cell cycle and differentiate into myotubes as well as myofibers.The plasticity of myoblasts plays a critical role in maintaining skeletal muscle structure and function by myoblast activation,migration,adhesion,membrane reorganization,nuclear fusion,finally forming myotubes/myofibers.Our studies demonstrate that the local hypoxic microenvironment,a great diversity of regulatory factors such as IL-6 superfamily factors(IL-6,LIF,CNTF) and TGF-β1 could regulate the myoblast plasticity.The aim of this paper is to review the previous studies focused on the regulation of myoblast plasticity and its mechanism in our laboratory.Knowledge about the microenvironment or factors involved in regulating the myoblast plasticity will help develop the prevention and cure measures of skeletal muscle diseases.The development of skeletal muscle is a highly regulated,multi-step process in which pluripotent mesodermal cells give rise to myoblasts that subsequently withdraw from the cell cycle and differentiate into myotubes as well as myofibers.The plasticity of myoblasts plays a critical role in maintaining skeletal muscle structure and function by myoblast activation,migration,adhesion,membrane reorganization,nuclear fusion,finally forming myotubes/myofibers.Our studies demonstrate that the local hypoxic microenvironment,a great diversity of regulatory factors such as IL-6 superfamily factors（IL-6,LIF,CNTF） and TGF-β1 could regulate the myoblast plasticity.The aim of this paper is to review the previous studies focused on the regulation of myoblast plasticity and its mechanism in our laboratory.Knowledge about the microenvironment or factors involved in regulating the myoblast plasticity will help develop the prevention and cure measures of skeletal muscle diseases.

关 键 词：成肌细胞 可塑性 机制 调控因子 IL-6 骨骼肌 细胞周期 CNTF 

分 类 号：Q813.11[生物学—生物工程] X172[环境科学与工程—环境科学]