血微量元素与肝硬化患者扑翼样震颤的关系研究  

Relationship between trace elements and flapping tremors in patients with liver cirrhosis

作　　者：张丽航[1] 毛峻岭[1] 任海峰[1] 王善娟[1] 张慧[1] 万坚[1] 刘艳丽[1] 王一飞[1] 林永辉[1] 

机构地区：[1]上海交通大学仁济医院嘉定分院消化内科,上海201800

出　　处：《胃肠病学和肝病学杂志》2012年第12期1090-1093,共4页Chinese Journal of Gastroenterology and Hepatology

基　　金：上海市嘉定区卫生局2008年科研项目(KYXM 2008-11-03)

摘　　要：目的观察肝硬化患者血微量元素的改变,了解血微量元素与肝性脑病严重程度、扑翼样震颤是否存在相关性。方法收集2008年6月-2010年10月在嘉定区中心医院消化内科住院的肝硬化患者及非肝硬化住院患者共90例,收集受试者一般资料、观察神志、体检有无扑翼样震颤、进行数字连接试验、抽血检测7种微量元素。根据体检将肝硬化患者分为无肝性脑病组、轻微肝性脑组病组及显性肝性脑病组。结果 30例非肝硬化住院患者作为对照组,60例肝硬化患者中无扑翼样震颤28例、有扑翼样震颤32例。无肝性脑病组33例、轻微肝性脑病组15例、显性肝性脑病组12例,各组间血铜、锌、钙、镁、铁、铅、镉差异均无统计学意义(P>0.05)。肝硬化组血锌(P<0.05)、血镁、血铁(P<0.01)比对照组低,且与扑翼样震颤存在相关性,而血铜、钙、铅、镉差异均无统计学意义(P>0.05),且与扑翼样震颤没有相关性。结论血锌、镁、铁下降可能是肝性脑病发病原因之一,而与血铜、钙、铅、镉不存在相关性。Objective To investigate the changes of serum trace elements in patients with liver cirrhosis and its possible relationship with the severity of hepatic encephalopathy or flapping tremor.Methods The inpatients with or without liver cirrhosis from Jun.2008 to Oct.2010 in the Gastroenterology of Jiading District Central Hospital were enrolled in this study.The general information,mind,flapping tremor in the physical examination,number connection test（NCT） and serum seven trace elements were detected.These patients were divided into group without hepatic encephalopathy,group with mild hepatic encephalopathy and group with severe hepatic encephalopathy according to the results of medical examination.Results 30 patients with non-liver cirrhosis were served as control.And there were 32 cases with flapping tremor in 60 patients with liver cirrhosis.There were 33 patients in the group without hepatic encephalopathy,15 patients in group with mild hepatic encephalopathy and 12 patients in the group with severe hepatic encephalopathy.There were no significant difference of serum copper,zinc,calcium,magnesium,iron,lead and cadmium among these three groups.Serum zinc,magnesium and iron were lower in group with cirrhosis than those in the control.In addition,there were correlation between these three indexes and flapping tremor.Also there were no significant differences of serum copper,calcium,lead and cadmium between group with cirrhosis and control group,while there was no correlation between these serum indexes and flapping tremor.Conclusion The decrease of the serum zinc,magnesium and iron may be one of etiological factors in hepatic encephalopathy.And there are no correlation among serum copper,calcium,lead and cadmium and flapping tremor.

关 键 词：肝硬化 肝性脑病 扑翼样震颤 微量元素 数字连接试验 轻微肝性脑病 

分 类 号：R575.2[医药卫生—消化系统]