肝内胆管结石合并胆管癌  

Hepatolithiasis combined with intrahepatic cholangiocarcinoma

作　　者：王广义[1] 王英超[1] 孙晓东[1] 

机构地区：[1]吉林大学白求恩第一医院肝胆胰外科,吉林省长春市130021

出　　处：《世界华人消化杂志》2012年第34期3336-3339,共4页World Chinese Journal of Digestology

摘　　要：肝内胆管结石在东亚地区是较为常见的疾病,是肝内胆管癌最主要的病因之一.胆管内结石对胆管壁的长期刺激,结石引起的胆管狭窄梗阻造成胆汁滞留及同时伴发的细菌感染等生物因素的慢性刺激,导致胆管壁的慢性增生性炎症,进而引起胆管上皮的不典型增生和上皮化生,发生癌变.本文主要对肝内胆管结石合并胆管癌的病因、临床表现、影像学诊断和病理特点、治疗方式等方面进行阐述.肝内胆管结石合并胆管癌的诊断和治疗均是对外科医生的巨大挑战.Hepatolithiasis is a relatively common disease in East Asian countries. It is one of the leading causes of intrahepatic cholangiocarcinoma. The long-term stimulation of bile duct stones and hepatolithiasis-induced bile duct stricture or ob- struction cause chronic irritation of cholestasis. In the presence of bacterial infection and other etiological factors, chronic proliferative inflam- mation of bile ducts will be caused. Eventually, biliary epithelial dysplasia, metaplasia, and even malignant transformation develop. In this paper, we describe the etiology, clinical mani- festations, pathological characteristics, imaging diagnosis, and treatment of hepatolithiasis with intrahepatic cholangiocarcinorna. Diagnosis and treatment of hepatolithiasis with intrahepatic cholangiocarcinoma represent a great challenge

关 键 词：肝内胆管结石 肝内胆管癌 

分 类 号：R735.8[医药卫生—肿瘤]