溃疡性结肠炎血清免疫学及SOD活性变化  

The study of ulcerative colitis, serum immunology and active change of SOD

作　　者：焦君良[1] 王生茂[1] 要丽英[1] 刘桂缺[1] 李士军[1] 

机构地区：[1]河北省中医药研究院,石家庄市050031

出　　处：《河北医药》2000年第7期497-498,共2页Hebei Medical Journal

摘　　要：目的　探讨溃疡性结肠炎的发病机制。方法　用免疫法制成大鼠溃疡性结肠炎实验模型 ,测定其血清有关免疫指标和SOD含量等 ,并与正常大鼠对照。结果　实验大鼠血清抗大肠抗体均见阳性 ,其血清IgA和IgG较正常显著增高 ,淋巴细胞转化率明显降低 ;血清SOD水平显著下降 ;结肠组织学检查 ,病变部位有明显溃疡形成 ,并有大量淋巴、单核和嗜中性细胞浸润。Objective To discuss the pathogensis of ulcerative colitis.Methods Experimental ulcerative colitis rats were made by the method of immunology and their immunological function and SOD in serums were oberved.Results In their serums, anti large intestine antibodies were all positive; IgA and IgG were higher than normal rats; the ability of lymphocyte transformation and SOD were lower than normal rats. Colitis tissue investigation showed that distinct ulcerative formation and much infiltration of lymphocytes, monocytes and neutrophils.Conclusion The pathogenesis of ulcerative colitis is related to the disorder of immunological function and the injure of free radical reaction.

关 键 词：溃疡性结肠炎 超氧化物歧化酶 免疫学 

分 类 号：R574.62[医药卫生—消化系统]