KLF6蛋白在肝细胞癌组织中的表达及其意义  

Expression of KLF6 protein in tissue of hepatocellular carcinoma and its significance

作　　者：朱海龙[1] 袁卫平[1] 岳惠芬[1] 欧超[1] 梁嵘[1] 

机构地区：[1]广西医科大学附属肿瘤医院肝胆外科,广西南宁530021

出　　处：《重庆医学》2013年第1期33-36,共4页Chongqing medicine

基　　金：广西医疗卫生重点科研课题(重200973)

摘　　要：目的探讨Kruppel样因子6(KLF6)蛋白在肝细胞癌中的表达以及与肝细胞癌发生、发展之间的关系。方法采用免疫组织化学链霉素抗生物素蛋白-过氧化物酶(SP)法检测48例原发性肝癌组织、癌旁组织及24例正常肝组织中KLF6蛋白的表达。结果 KLF6蛋白在肝癌组织、癌旁组织的阳性表达率明显高于正常肝组织(P<0.05);KLF6蛋白表达与肝功能Child-Pugh分级正相关(P<0.05);男性患者肝癌组织KLF6蛋白的表达高于女性患者(P<0.05);KLF6蛋白的表达与年龄、甲胎蛋白、肿瘤直径、肝硬化、乙型肝炎病毒感染、远处转移和门静脉癌栓无明显相关(P>0.05)。结论 KLF6蛋白在肝癌组织和癌旁组织中高表达,KLF6基因与肝细胞癌的发生、发展有关。Objective To investigate expression of Kruppel-like factor 6（KLF6） protein in hepatocellular carcinoma and its cor- relation with occurrence and development of hepatocellular carcinoma. Methods Streptavidin perosidase（SP） immunohistochemical technique was used to detect the expression of KI.F6 protein in 48 cases of primary hepatoeellular carcinoma tissue and pericarcino- matous tissue and 24 eases of normal hepatic tissue. Results Rates of KI.F6 protein positive expression in tissue of hepatocellular carcinoma and periearcinoma were significantly higher than that in normal hepatic tissue（P（0.05）. Its expression correlated posi- tively with liver function Child Pugh score（P^0.05）. Male patients demonstrated higher KI.F6 protein expression level in hepato cellular carcinoma tissue than female（P（0.05）. KI.F6 protein showed no significant correlation with age, alpha fetoprotein, tumor diameter,cirrhosis,hepatitis B virus infection, distant metastasis and portal vein tumor thrombus （P〉0.05）. Conclusion KLF6 protein is highly expressed in hepatocellular carcinoma tissue and pericarcinomatous tissue,and KLF6 gene is correlated with occurrence and development of hepatocellular carcinoma.

关 键 词：癌 肝细胞 免疫组织化学 蛋白 KLF6 

分 类 号：R735.7[医药卫生—肿瘤]