子宫内膜癌中E2F-1和p-p38的表达及意义  

Expression and significance of E2F-1 and p-p38 in endometrial carcinoma

作　　者：周海霞[1] 时志民[2] 王蕾[2] 司军英[3] 吴彩花[4] 

机构地区：[1]河北省邯郸市中西医结合医院,河北邯郸056002 [2]河北工程大学医学院,河北邯郸056001 [3]河北省邯郸市中心医院,河北邯郸056001 [4]河北省邯郸市传染病医院,河北邯郸056002

出　　处：《现代中西医结合杂志》2013年第2期123-124,130,共3页Modern Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的检测子宫内膜癌组织中E2F-1和p-p38表达情况并探讨其意义。方法采用免疫组织化学S-P法检测60例子宫内膜癌、32例正常子宫内膜组织中E2F-1和p-p38的表达情况。结果子宫内膜癌组织中E2F-1和p-p38表达定位于细胞核,其阳性表达率分别为58%(35/60)和55%(33/60);而正常子宫内膜组织均无表达。两者的表达与肌层浸润程度、淋巴结转移、临床分期及病理分期有关;在子宫内膜癌组织中E2F-1和p-p38两者之间比较表达呈正相关(P<0.05)。结论 E2F-1和p-p38在子宫内膜癌中呈高表达,且与子宫内膜癌的发生、发展和转移密切相关。Objective It is to determine the expression of E2F-1 and p-p38 in the endometrial carcinoma and to explore the significance.Methods The expressions of E2F-1 and p-p38 in 60 cases of endometrial cancer and 32 cases of normal endometrial tissue by immunohistochemistry S-P method.Results The expressions of E2F-1 and p-p38 were located with the cytoplasm and the endometrial,and their positive expression rates were 58%（35/60） and 55%（33/60） respectively which were significantly higher than that in normal endometrial tissue.All of their expressions were related with myometrial invasion,lymph nodemetastasis,clinical stage and pathological staging（P0.05）.In endometrial carcinoma,the expressions of E2F-1 and p-p38 were positively correlated with each other（P0.05）.Conclusion E2F-1 and p-p38 were highly expressed in the endometrial cancinoma and their expressions were related with the development and metastasis of endometrial carcinoma.

关 键 词：子宫内膜癌 E2F-1 P-P38 免疫组化 

分 类 号：R737.33[医药卫生—肿瘤]