促红细胞生成素对颅内动脉瘤术后脑缺血的疗效观察  

Efficacy of erythropoietin on postoperative cerebral ischemia in patients after intracranialaneurysm surgery

作　　者：张树葆[1] 张学广[1] 李忠民[1] 耿凤阳[1] 郭传军[1] 肖以磊[1] 种宗雷[1] 

机构地区：[1]聊城市人民医院神经外科,252000

出　　处：《中华神经医学杂志》2013年第1期50-52,共3页Chinese Journal of Neuromedicine

摘　　要：目的观察促红细胞生成素（EPO）对颅内动脉瘤术后脑缺血患者的治疗作用。方法选择自2006年5月至2010年8月在山东省聊城市人民医院神经外科行颅内动脉瘤手术，且术后发现脑缺血的60例患者，按照随机数字表法分为对照组和治疗组，每组30例。治疗组在常规治疗基础上给予EPO皮下注射，剂量为3000IU，连用3d。对照组在常规治疗基础上给予同等剂量生理盐水治疗。利用美国国立卫生研究院卒中量表（YIHSS）对2组患者人院当天、EPO／生理盐水治疗后1、2、3、4、5周各进行一次评分。利用MRI弥散加权成像（DWI）测定缺血当天及缺血后1、2、3、4、5周时2组患者脑缺血面积。结果治疗第3、4、5周时，治疗组与对照组NIHSS评分分别为（9．4±1．9）vs（11．3±2.3）、（8．7±1．7）vs（10．8±2．2）、（7．9±1．6）vs（10．1±2．3），差异有统计学意义（P〈0．05）。同时，治疗第3、4、5周，治疗组与对照组脑缺血面积缩小百分率的差异也有统计学意义（P〈0．05），具体值分别为（21．6±4．1）％vs（16．8±3．1）％、（27．5±5.3）％vs（18．9±3．3）％、（32．8±5．5）％vs（19．5±3．4）％。结论EPO能够通过促进缺血脑组织微循环重建的机制起到神经保护作用。Objective To investigate the efficacy of erythropoietin （EPO） on cerebral ischemia of patients after intracranial aneurysm surgery. Methods Sixty patients with cerebral ischemia after operation of intracranial aneurysm, admitted to our hospital from May 2006 to August 2010, were randomly divided into control and treatment groups （n=30）. Control group received conventional treatment, while the other group, on the basis of conventional therapy, was hypodermically given EPO at a dosage of 3000 IU for a consecutive 3 days. U.S. National Institutes of Health Stroke Scale （NIHSS） was used to score the patients on the admission day, 1, 2, 3, 4 and 5 weeks after EPO treatment; and diffusion-weighted imaging （DWI） of MRI was used in determining the changes of cerebral ischemic area on the ischemic day and 1, 2, 3, 4 and 5 weeks after ischemic. Results NIHSS scores of the EPO group （9.4±1.9, 11.3±2.3, 8.7±1.7） at 3, 4 and 5 weeks after treatment were significantly higher as compared with those in the control group （10.8±2.2, 7.9±1.6, 10.1±2.3） （P〈0.05）. Similarly, 3, 4 and 5 weeks after treatment, the reducing percentage of cerebral ischemia area in the EPO group （21.6±4.1, 27.5±5.3, 32.8±5.5）% was larger than that in the control group （16.8±3.1, 18.9±3.3, 19.5±3.4）% （P〈 0.05）. Conclusion EPO may play an effective role in cerebral ischemia of patients after intracranial aneurysm operation.

关 键 词：促红细胞生成素 颅内动脉瘤 脑缺血 疗效观察 

分 类 号：R743.31[医药卫生—神经病学与精神病学]