皮肤原发性B淋巴母细胞淋巴瘤一例  

A case of primary cutaneous B-ceU lymphoblastic lymphoma

作　　者：曲延刚 唐爱萍 王红莉 李虹 陈甦 

机构地区：[1]湖北省恩施州中心医院病理科,445000 [2]青岛市崂山区妇幼保健院

出　　处：《国际皮肤性病学杂志》2013年第1期7-8,共2页International Journal of Dermatology and Venereology

摘　　要：患者男，56岁。2006年发现左前臂隆起性结节半年，渐增大。皮肤科检查：左前臂外侧可见一直径3cm的肿物，其皮肤表面颜色略深，可见手术瘢痕长2．5cm，肿物与皮肤粘连，固定，边界不清。组织病理学检查：瘤细胞圆形、卵圆形，小至中等大的淋巴母细胞，染色质细腻，核仁不明显，胞质少而淡染，弥漫分布。免疫组化：末端脱氧核苷酸转移酶（TDT）＋、LCA＋、CD20-、CD79a＋、转录因子PAX5＋、CD3-、CD30-、Ki-67阳性细胞数50％、上皮膜抗原（EMA）-、CD5-、CD10＋、CD23-、CD56-。病理诊断：皮肤B淋巴母细胞淋巴瘤。治疗：给予环磷酰胺＋多柔比星＋长春新碱＋泼尼松（CHOP）方案化疗，病情反复，随访4年9个月时患者死亡。A 56-year old man developed a raised nodule on the left forearm half a year before 2006, which gradually enlarged. Skin examination revealed a mass measuring 3 cm in diameter at the extensor aspect of left forearm, which was fixed, slightly deep-colored, adherent to the skin with an unclear margin. There was a postoperative scar measuring 2.5 em in length. Histopathological examination revealed small- to medium- sized round or oval lymphocytes with fine chromatin, unclear nucleoli, a small amount of lightly stained cytoplasm. Immunophenotype analysis showed that the tumor cells were positive for terminal deoxynucleotidyl transferase （TDT）, leucocyte common antigen （LCA）, PAX5 （paired box 5）, CD79a, CD10, Ki-67 （50%）, but negative for CD20, CD3, CD30, epithelial membrane antigen （EMA）, CD5, CD23 and CD56. He was pathologically diagnosed with cutaneous B-cell lymphoblastic lymphoma, and given combination chemotherapy with eyclophosphamide, doxorubiein, vineristine and prednisone. Unfortunately, the condition was poorly controlled, and the patient died 4 years and 9 months later.

关 键 词：淋巴瘤 淋巴母细胞 病例报告[文献类型] 

分 类 号：R733.1[医药卫生—肿瘤]