STAT3和VEGF在皮肤黑素瘤中的作用及研究进展  

Roles of signal transducer and activator of transcription 3 and vascular endothelial growth factor in cutaneous melanoma： an update

作　　者：殷芳[1] 宋宁静 王晓楠[3] 

机构地区：[1]安徽医科大学上海皮肤病临床学院,上海200443 [2]上海市皮肤病医院 [3]安徽医科大学病原与免疫学实验中心

出　　处：《国际皮肤性病学杂志》2013年第1期28-31,共4页International Journal of Dermatology and Venereology

基　　金：基金项目：上海市自然科学基金（11ZR1432900）;上海市卫生局科研项目（20114125）;安徽医科大学科研基金（2012xkj001）

摘　　要：信号转导和转录活化因子3是信号转导和转录活化因子家族的重要成员，参与调控相关靶基因表达，是多种致癌途径的焦点，其持续性激活能导致肿瘤的发生。信号转导和转录活化因子通过调节细胞凋亡抑制因子（Bcl-xL、Bel-2、生存素）、细胞周期调节因子（细胞周期调节因子D1、细胞周期调节因子D2、原癌基因）以及血管生成诱导因子（血管内皮生长因子、环氧化酶-2、基质金属蛋白-9）等相关调控因子，在细胞增殖、存活、凋亡、分化及转移等过程中起作用。血管内皮生长因子是目前已知最重要的促血管生成因子之一，对肿瘤血管基质形成及肿瘤生物学行为均有重要影响，可作为肿瘤代谢及转移的标志。主要就信号转导和转录活化因子3、血管内皮生长因子及其相关调控基因在皮肤黑素瘤中发生、发展中所起的作用及其可能的机制做进一步阐述，以信号转导和转录活化因子3、血管内皮生长因子为靶点的联合治疗有单为皮肤黑素瘤的治疗提供新的思路．Signal transducer and activator of transcription 3 （STAT3）, known as an important member of the STAT family and the focus of many carcinogenic pathways, is involved in the regulation of gene expression, and its continuous activation is associated with the development of tumors. STAT plays an important role in cell proliferation, survival, apoptosis, differentiation and metastasis by modulating some regulatory factors, such as cell apoptosis-inhibiting factors （Bcl-xL, Bcl-2, survivin）, cell cycle-regulating factors （cyclin-D1, cyclin-D2, c-myc） and angiogenesis-inducing factors （vascular endothelial growth factor （VEGF）, cyclooxygenase 2 （COX-2）, matrix metalloproteinase-9 （MMP-9））. VEGF is now believed to be the most important angiogenic factor with a considerable effect on both vascular stroma formation and biological behavior of tumors, and can serve as a marker of tumor metabolism and metastasis. This paper elucidates the function and possible mechanisms of STAT3, VEGF and relevant regulatory genes in the initiation and progression of cutaneous melanoma, which may provide new ideas for the targeted therapy of cutaneous melanoma.

关 键 词：黑色素瘤 STAT3转录因子 血管内皮生长因子A 

分 类 号：R73[医药卫生—肿瘤]