降纤酶治疗急性脑梗死临床对照观察  

The Clinical Observation of Acute Cerebral Infarctions Treated with Defibrase

作　　者：汪志云[1] 刘津[1] 李蕴琛[1] 郭洁[1] 

机构地区：[1]天津市第一中心医院神经内科,天津300190

出　　处：《蛇志》2000年第1期39-40,共2页Journal of Snake

摘　　要：目的　验证降纤酶治疗急性脑梗死的临床疗效及其血液学的改变。　方法　采用病历与对照的方法将病例随机分为两组。降纤酶组 1 42例 (治疗组 ) ,低分子右旋糖酐组 4 0例 (对照组 ) ,治疗前两组纤维蛋白原和神经功能缺损程度评分无差异 ( P >0 .0 5)。　结果　治疗后 3天神经功能缺损程度评分两组比较有差异 ( P <0 .0 5) ,治疗后 1 4天两组有显著性差异 ( P <0 .0 0 1 )。降纤酶治疗急性脑梗死的总有效率为 90 .1 %( 1 2 8/1 42 ) ,而低分子右旋糖酐治疗的总有效率为 62 .5%( 2 5/4 0 )。　结论　治疗后 3天、 7天 ,治疗组和对照组之间纤维蛋白原有显著性差异 ( P <0 .0 0 1 ) ,其升高除引起血浆粘度增高以外 ,还与血栓形成有密切关系 ,且在血小板的粘附和聚集中起桥梁作用。降纤酶治疗后 7天 ,血纤维蛋白原开始回升。Objective In this paper it is to determine the clinical effects and laboratory changes of acute cerebral infarctions treated with defibrase Method The cases studied were divided into two groups:142 cases in the defibrase group and 40 cases in the low molecular weight dextran group,as control There were some differences of serum fibrinogen content and neurofunction defect evaluated in the two groups before treatment(P>0 05)  Result Three days after treatment there were some differences in the neurofunction evaluated between the two groups(P<0 05)  14 days after treatment there were significant differences between the two groups(P<0 001) The total effects of defibrase in treating acute cerebral infarctions were 90 1%(128/142),and that of low molecular weight dextran were 62 3% Conclusion After the treatment of 3 days and 7 days,the amount of serum fibrinogen of the two groups had significant differences(P<0 001) The elevation of serum fibrinogen could make the elevation of plasma viscosity and be related tightly with thrombosis It could have a bridging effect in platelet adhesion and aggregation 7 days after defibrase treatment the serum fibrinogen content began to elevation

关 键 词：降纤酶 急性脑梗死 疗效试验 蛇毒制剂 安全性 

分 类 号：R743.305[医药卫生—神经病学与精神病学] R973.2[医药卫生—临床医学]