国产降纤酶治疗脑梗死的前瞻性随机双盲对照研究  

The Clinical Studies on Make in China Defibrase Treated the Cerebral Infarction with Double Blind and Comparative Method

作　　者：于增盛 孙顺昌[1] 王淑玲[1] 王玉洪[1] 李武伦[1] 

机构地区：[1]青岛市第八人民医院,山东青岛266100

出　　处：《蛇志》2000年第1期41-43,共3页Journal of Snake

摘　　要：目的　应用全国脑防办双盲编号的国产降纤酶静滴治疗发病 2 4 h以内的急性脑梗死病人 3 4例。　方法　降纤酶治疗组 2 1例 ,对照组 1 3例。在应用降纤酶治疗前进行神经功能缺损评分。在出院时和第 1 2周进行病人日常生活功能的评估 ( Barthel氏指数 )。并于治疗前后检测血浆纤维蛋白原含量、肝、肾功能。　结果　近期疗效降纤酶治疗组优于对照组 ,神经功能缺损评分亦优于对照组 ,但不具备统计学显著性差异 ( 0 .2 <P<0 .3 )。病人第 1 2周日常生活能力评估 ( Barthel氏指数 )较出院时有显著进步 ( P <0 .0 0 1 )。　结论　国产降纤酶确为有效降低血浆纤维蛋白原的药物 ,对急性脑梗死治疗有一定的疗效。Objective 34 patients with acute cerebral infarction with 24 hours were treated with defibrase injected numbered by the national brain disease treatment and preventive office with double blind Methods 21 patients treated with defibrase, and 13 patients as the control The nerve function deficit score was evaluated before treatment, and the routine life ability(Barthel index) was evaluated at the time of discharged, and the 12th week The serum fibrinogen concentration, hepatic function, and nephritic function were tested before and after treated with defibrase  Results The effect of early period and nerve function deficit score with defibrase improved much more than those of the control group But without significant difference(0 2<P<0 3)  The routine life ability at the time of the 12th week improved apparently than that of discharged(P<0 001) The fibrinogen concentration was decreased significantly than that of the control group(P<0 001) Conclusion That the defibrase made in China was an effective drug to decrease the fibrinogen concentration and treat the acute cerebral infarction

关 键 词：降纤酶 脑梗死 前瞻性随机双盲 疗效试验 

分 类 号：R743.305[医药卫生—神经病学与精神病学] R973.2[医药卫生—临床医学]