环孢霉素A滴眼液治疗单疱病毒性角膜基质炎疗效观察  

Curative effect of cyclosporin A eye drops on treatment of herpetic stromal keratitis

作　　者：秦光勇[1] 刘莉[1] 吴湘[1] 

机构地区：[1]黄石爱尔眼科医院,中国湖北省黄石市435002

出　　处：《国际眼科杂志》2013年第1期161-162,共2页International Eye Science

摘　　要：目的:观察10g/L环孢霉素A滴眼液治疗单疱病毒性角膜基质炎临床疗效。方法:我院2011-01/2012-01治疗单疱病毒性角膜基质炎患者91例91眼,随机分为两组,A组应用10g/L环孢霉素A滴眼液和更昔洛韦凝胶,B组应用5g/L氯替泼诺滴眼液和更昔洛韦凝胶,其余均为对症治疗,随诊观察6～12(平均10)mo。结果:两组治疗单疱病毒性角膜基质炎疗效无显著性差异,但A组治愈时间平均5.1±2.4d,B组治愈时间平均6.2±2.8d,A组较B组平均治愈时间短。两组治愈率及复发率无统计学差异。结论:对于单疱病毒性角膜基质炎患者应用10g/L环孢霉素A滴眼液能够安全有效治愈,且治愈时间短。AIM：To observe the clinical curative effect of cyclosporine A eye drops on the treatment of herpetic stromal keratitis.METHODS：From January 2011 to January 2012,91 cases 91 eyes with herpes simplex virus keratitis patients in our hospital were randomly divided into two groups：group A received 10g/L cyclosporin A eye drops and ganciclovir gel;group B was used 5g/L loteprednol etabonate ophthalmic solution and ganciclovir gel.The rest were symptomatic treatment.Two groups were followed up for 6-12 months,with an average of 10 months.RESULTS：There was no significant difference in treatment effect of viral keratitis between two groups.But the average cure time in group A was 5.1±2.4 days,and that of group B was 6.2±2.8 days,indicating that the average cure time in group A was shorter than group B.The two group cure rate and recurrence rate had no statistical difference（P 0.05）.CONCLUSION For herpes simplex virus keratitis patients,using 10g/L cyclosporin A eye drops can be safe and effective,but the cure time is long.

关 键 词：环孢霉素A滴眼液 氯替泼诺滴眼液 单疱病毒性角膜基质炎 

分 类 号：R772.21[医药卫生—眼科]