人类基因组中的反转录转座子  

Human Retrotransposons

作　　者：刘新文[1] 童坦君[1] 张宗玉[1] 

机构地区：[1]北京医科大学生物化学与分子生物学系,北京100083

出　　处：《生物化学与生物物理进展》2000年第1期9-12,共4页Progress In Biochemistry and Biophysics

基　　金：国家自然科学基金!资助重点项目 (39930 1 70 )

摘　　要：人类基因组中有35%以上的序列为转座子序列.反转录转座子是引起人类疾病的潜在病因.人类基因组中的主导转座子———L1反转录转座子内部有二个开放读框,其编码蛋白具有RNA结合蛋白、反转录酶和内切酶活性.L1可能通过靶引物反转录机制整合到染色体中;Alu等非自主性反转录转座子可能利用L1反转录酶的反式互补作用进行转座.At least 35% of the human genome is made up of transposon DNA. Retrotransposons are potential causal agents of human disease. The mast human mobile element, L1 retrotransposon, has 5′,3′ UTR and two ORFs which encode a sequence specific RNA banding protein and a protein containing an endonuclease (EN) domain and a reverse transcriptase (RT) domain. Its likely that L1 undergoes target primed reverse transcription in order to carry out retrotransposon. The mobilization of the non autonomous retrotransposons, such as Alu and processed pseudogens, require a cellular source of reverse transcriptase, which is most likely encoded by L1.

关 键 词：反转录转座子 人类基因组 人类疾病 L1 

分 类 号：Q987[生物学—遗传学] R394[生物学—人类学]