老年轻度认知功能障碍影响因素的研究进展  

A study on influential factors for mild cognitive impairment in elder people

作　　者：周良佳[1] 马菲[2] 

机构地区：[1]东南大学公共卫生学院,江苏南京210009 [2]天津医科大学公共卫生学院

出　　处：《现代预防医学》2013年第2期306-311,共6页Modern Preventive Medicine

摘　　要：轻度认知功能障碍是正常老化与早期老年性痴呆之间的一种过渡阶段,研究轻度认知功能障碍最重要的意义在于识别痴呆高危个体,即发现具有最佳干预时机的个体,并探索有效的干预途径,以便延迟或阻止痴呆的发生、发展。但轻度认知功能障碍的发病机制极为复杂,与多种因素相关。本文就社会人口因素(年龄、性别、受教育程度等),疾病史(高血压、糖尿病等),遗传学基因学指标(ApoE基因、APP基因、早老素1、早老素2基因等),心理学因素(抑郁、人格特征),行为和生活方式因素(体育锻炼、地中海饮食方式、吸烟、饮酒)等方面对MCI的危险因素进行综述,以期为进一步研究提供参考。The term of mild cognitive impairment （MCI） refers to the transitional state between normal aging and early dementia. The aim of researching mild cognitive impairment is to identify individuals at high risk of dementia, who are at the best time for intervention, and to explore effective intervention methods to delay or prevent the occurrence of dementia. However, the pathogenesis of mild cognitive impairment is extremely complicated, which relates to many factors. This review looks into influential factors for mild cognitive impairment （MCI） in elderly, such as socio-demographic factors （including age, gender, educational level, etc）, disease （including hypertension, diabetes, etc）, genetic factors （including ApoE genotype, APP gene, presenilin 1, presenilin 2, etc）, psychological factors （including depression and personality features） and lifestyle factors （including physics, Mediterranean-type diet, smoking and alcohol intake） .

关 键 词：轻度认知功能障碍 影响因素 APOE基因 心理学因素 

分 类 号：R749.16[医药卫生—神经病学与精神病学]