MicroRNA对动脉粥样硬化发生的调控作用及其临床应用  

The Role of MicroRNA in Atherosclerosis Pathogenesis and Its Clinic Use

作　　者：宋翠珠[1] 郭韧[2] 张毕奎[2,1] 

机构地区：[1]中南大学药学院,长沙410078 [2]中南大学湘雅第三医院,长沙410078

出　　处：《中国生物化学与分子生物学报》2013年第1期13-18,共6页Chinese Journal of Biochemistry and Molecular Biology

基　　金：国家自然科学基金项目(No.81000120)资助~~

摘　　要：MicroRNA(miRNA)是新发现的基因表达调控因子,由长约21～25个核苷酸的单链RNA分子构成,是非编码小RNA.它可以通过与特定mRNA的3'非翻译区(3'-untranslated region,3'UTR)相结合,抑制mRNA编码蛋白质的翻译过程来调控基因表达.动脉粥样硬化(atherosclerosis,AS)是一种慢性炎症性疾病,是多种心血管疾病的病理基础.最近,研究发现多个miRNA与动脉粥样硬化的发生发展有关,且其在血液和体液中稳定存在并高度保守.本文主要综述了miRNA对动脉粥样硬化进程的调节作用及以其为靶点的相关临床研究,旨在阐明miRNA成为动脉粥样硬化诊断与治疗新靶点的重要意义.MicroRNAs （miRNAs） are a classical single-stranded, endogenous short RNA molecules （about 21 to 25 nucleotides） that is able to regulate target gene expression by binding to specific base-paired mRNA targets in the 3′-untranslated region （UTR）. Atherosclerosis is a chronic inflammatory disorder that leads to the pathological changes of cardiovascular disease. Recent studies have shown that multiple miRNAs participated in the initiation and development of atherosclerosis. We reviewed the important discoveries about the roles of miRNAs in atherosclerosis progression, as well as the candidate miRNAs that might be used as the targets for atherosclerosis therapies.

关 键 词：动脉粥样硬化 MICRORNA 血管内皮细胞 单核 巨噬细胞 血管平滑肌细胞 

分 类 号：R394.3[医药卫生—医学遗传学] R543.5[医药卫生—基础医学]