首发精神分裂症患者体质量指数与脑灰质体积比率的相关性  

Relationship Between Body Mass Index and Volume Ratio of Brain Gray Matter in Patients with First-episode Schizophrenia

作　　者：李娜[1] 邓伟[1] 何宗岭[1] 李名立[1] 黄明敏[1] 李涛[1] 邓红[1] 

机构地区：[1]四川大学华西医院心理卫生中心,成都610041

出　　处：《四川大学学报（医学版）》2013年第1期76-79,共4页Journal of Sichuan University(Medical Sciences)

基　　金："十一五"科技支撑项目(No.2007BAI17);国家自然科学基金(No.30670757)资助

摘　　要：目的分析未经治疗的首发精神分裂症患者体质量指数(body mass index,BMI)与年龄、脑体积指标、精神病性症状的相关性,以探讨首发精神分裂症的特征性BMI异常。方法未用药首发精神分裂症患者97例及与之相匹配的健康对照97例纳入本研究。测评BMI,做磁共振扫描,评定患者的精神病性症状。结果①两组间BMI值、白质体积值、灰质体积值、灰质体积比率差异无统计学意义。②相关分析:健康对照组BMI与年龄呈正相关(r=0.42,P=0.001),与脑灰质体积(r=-0.33,P=0.012)及脑灰质体积比率呈负相关(r=-0.39,P=0.003),与白质体积不存在相关性。患者组上述相关性消失,且没有发现BMI与阳性与阴性症状量表总量表分或各因子分存在相关性。结论对正常青壮年BMI的研究,发现其与年龄呈正相关,与灰质体积比率呈负相关。首发精神分裂症患者BMI与年龄和脑灰质体积比率的相关性消失,且该异常独立于临床症状存在。Objective To analyze the relationship between psychotic symptoms and body mass index （BMI） and brain mass index in patients with first-episode schizophrenia. Methods We identified 97 patients with first- episode and drug-free schizophrenia and compared their BMI and scare MRI results with 97 healthy participants. Results There were no statistically significant differences in BMI, volume oI white matter and volume of grey matter between the patients with schizophrenia and healthy participants. BMI was positively correlated with age and negatively correlated with gray matter volume and the ratio of gray matter volume in the healthy participants. No such correlations were found in the patients with schizophrenia. BMI were not correlated with the total score of PANSS, nor with the factor score of PANSS. Conclusion BMI is positive correlated with age, but negatively correlated with gray matter volume and the ratio of gray matter volume in healthy adult. But such correlations disappear in patients with schizophrenia. BMI is not associated with the seriousness of psychotic symptoms.

关 键 词：首发精神分裂症患者 体质量指数 脑灰质体积比率 年龄 

分 类 号：R749.3[医药卫生—神经病学与精神病学]