连续和间断运动对高脂饮食大鼠肥胖和脂肪肝作用效果的比较  

Effect of intermittent versus continuous exercise on obesity and fatty liver in rats fed with high-fat diet

作　　者：杨敏丽[1] 李云川[1] 张忍发[1] 

机构地区：[1]昆明医科大学休育部,云南昆明650500

出　　处：《南方医科大学学报》2013年第1期61-65,共5页Journal of Southern Medical University

基　　金：国家体育总局青少年体育研究重点基金(2011QSS2011014);云南省教育厅科学研究基金重点基金(2012Z087)

摘　　要：目的探讨连续运动与间断运动对高脂饮食大鼠肥胖和脂肪肝的作用效果。方法根据饮食结构不同分为常规饮食(R)和高脂饮食(H)两大组,再根据运动的不同又分为静坐组(S)、连续运动组(CE)和间断运动组(IE),随机将Wistar大鼠分为6组(n=8)。CE组大鼠每天游泳1次,90 min/次;IE组大鼠每天游泳3次,30 min/次,每隔4 h 1次;两组每周运动5 d,持续8周。重量分析法测定:腹膜后(RET)、附睾(EPI)和内脏(VIS)的白色脂肪组织、棕色脂肪组织(BAT)、肝脏(L)和腓肠肌(GAST)。体内脂肪生成率测定:3H20与皂化后脂肪结合计算脂肪生成率。测定血总胆固醇(CHOL)、高密度脂蛋白胆固醇(HDL-C)、甘油三酯(TG)的含量。每天记录体质量和摄食量。结果间断运动能够改善血脂,减轻增加的体质量、中心性和内脏性肥胖和脂肪肝,能对控制肥胖症和相关并发症包括非酒精性脂肪肝疾病有效;间断运动在减少高脂饮食和久坐状态引起的肥胖和脂肪肝等不良反应方面较连续运动更有效;高脂饮食和不同运动方案对大鼠体质量增加、肥胖症、脂肪肝以及血脂的影响与运动方式、间隔时间、年龄、性别和实验周期有关。结论间断运动是一种非药物治疗控制肥胖及其他并发症的重要措施。Objective To examine the effects of continuous and intermittent exercises on obesity and fatty liver in rats fed with high-fat diet. Methods Wistar rats were randomly assigned into routine diet （R） and high-fat diet （H） groups, and each group were subdivided into sedentary group （S）, continuous exercise （CE） group, and intermittent exercise （IE） group （n=8）. In the CE group, the rats were forced to swim continuously for 90 min once daily and those in the IE group swam for 30 min for 3 times （at a 4-h interval） daily. Both the CE and IE groups exercised for 5 days a week for 8 consecutive weeks. After the experiment, the retroperitoneal, epididymal, and visceral white and brown adipose tissues, the liver, and the gastrocnemius muscle of the rats were weighed. The lipogenesis rate was determined by incorporation of 3H20 into saponified lipids, and the blood lipid profiles were analyzed. The body weight and food intake of the rats were recorded daily. Results IE appeared to be more efficient than CE in reducing the adverse effects of high-fat diet and sedentarism. Compared with CE, IE resulted in an improved lipid profile with reduced food intake, body weight gain, visceral and central adiposity, and fatty liver. The effect of high-fat diet and different exercises on weight gain, adiposity, fatty liver, and lipid profile in rats was associated to the manner of exercise, time of each session, age, gender, and length of observation period. Conclusion Intermittent exercise is an important nonpharmacological strategy to control obesity and the related complications.

关 键 词：间断运动 连续运动 肥胖 脂肪肝 高脂饮食 

分 类 号：R589.2[医药卫生—内分泌] R575.5[医药卫生—内科学]