血管紧张素原基因M235T及α-内收蛋白基因G460T多态性与脑梗死的关系  

Relationship between the gene polymorphisms of angiotensinogen gene M235T and α-adducin G460T gene and cerebral infarction

作　　者：李宏芬[1] 王颖杰[1] 沈志霞[1] 

机构地区：[1]河北联合大学附属开滦医院检验科,唐山063000

出　　处：《临床神经病学杂志》2012年第6期410-412,共3页Journal of Clinical Neurology

摘　　要：目的探讨血管紧张素原(AGT)基因M235T及α-内收蛋白基因G460T多态性与脑梗死的关系。方法采用PCR-限制性片段长度多态性(RFLP)方法检测396例脑梗死患者(脑梗死组)和360名健康体检者(正常对照组)AGT基因M235T及α-内收蛋白基因G460T基因型及等位基因频率,分析其与脑梗死的关系。结果 (1)脑梗死组AGT MM基因型频率明显低于正常对照组,MT基因型频率明显高于正常对照组(均P<0.05);两组间等位基因频率差异无统计学意义。(2)两组间α-内收蛋白G460T基因型及等位基因频率差异无统计学意义。(3)脑梗死组MM+GG频率显著少于正常对照组(P<0.05)。结论 AGT基因MT基因型可能与脑梗死发病有关;α-内收蛋白基因G460T多态性可能与脑梗死的发病无关;MM+GG基因型组合可能为脑梗死发病的保护因素。Objective To explore the relationship between the polymorphisms of angiotensinogen（AGT） gene M235T and α-adducin gene G460T and cerebral infarction（CI）.Methods PCR-restriction fragment length polymorphism（RFLP） was used to detect the genotype and allele frequencies of AGT M235T and α-adducin G460T in 396 CI patients（CI group） and 360 health physical examination persons（NC group）.The relationship between them and CI were analyzed.Results（1） The frequency of AGT MM genotype in CI group was significantly lower and MT genotype was significantly higher than NC group（allP0.05）,but the allele frequencies were no significantly different between the two groups.（2）The genotypes and allele frequencies of α-adducin G460T were no significantly different between the two groups.（3） Frequency of GG＋MM in CI group was significantly lower than NC group（P0.05）.Conclusions AGT gene MT genotype maybe relation to the onset of CI.The polymorphism of α-adducin gene G460T maybe not related to CI.The combination of GG＋MM genotypes maybe a protective factor of CI.

关 键 词：脑梗死 血管紧张素原 Α-内收蛋白 基因多态性 

分 类 号：R743.3[医药卫生—神经病学与精神病学]