FibroScan技术判断乙型肝炎肝硬化患者食管静脉曲张程度的临床研究  

FibroScan can be used to diagnose the size of oesophageal varices in patients with HBV-relatedcirrhosis

作　　者：李梵 闫涛[3] 张健[2] 邵清[2] 李冰[2] 李忠斌[2] 陈国凤[2] 

机构地区：[1]解放军医学院,北京100853 [2]解放军第三〇二医院肝纤维化诊疗中心 [3]解放军第三〇二医院国际肝病科

出　　处：《中华实验和临床病毒学杂志》2012年第6期470-473,共4页Chinese Journal of Experimental and Clinical Virology

基　　金：中国肝炎基金会王宝恩肝纤维化基金重点项目（xjs20110408）,面上项目（xjm02）;国家科技重大专项子课题（2011zx09201-201）

摘　　要：目的研究FibroScan对于乙型肝炎肝硬化患者食道静脉曲张程度的诊断效能。方法入选乙型肝炎肝硬化患者158例，所有患者进行胃镜及FibroScan检测。对比不同食道静脉曲张程度患者Fs值（FibroScan检测值）差异，绘制相应ROC曲线。结果无食道静脉曲张患者、轻度食道静脉曲张患者、中度食道静脉曲张患者和重度食道静脉曲张患者的Fs值分别是（21．7±9．9）kPa、（32．1±13．6）kPa、（42．3±20．0）kPa、（54．5±16．2）kPa。各组间比较差异有统计学意义（F值33．4，P〈0．001）；组间两两比较，差异均有统计学意义（P均〈0．05）。Fs值判断是否存在静脉曲张、判断中重度静脉曲张和判断重度静脉曲张的ROC曲线下面积分别为0．798（95％CI：73．1％～86．5％）、0．823（95％CI：74．5％～90．O％）和0．879（95％CI：80．8％～95．O％），对应界值分别是23．3kPa、31．5kPa和34．6kPa。结论FibroScan检测可以用来判断乙型肝炎肝硬化患者食道静脉曲张程度。Objective To study ability of FibroScan （FS） in diagnosing the size of oesophageal varices （OV） in patients with HBV-related cirrhosis. Methods A total of 158 patients with HBV-related liver cirrhosis were enrolled in the study. The relation between the presence of OV assessed by endoscopy, and liver stiffness measurement by Fibroscan was studied, and ROC curves were drawn to assess the diagnostic ability of FS value. Results For the patients without OV, mild OV, moderate OV, and severe OV, their corresponding FS values were （21.7 ±9. 9） kPa, （32. 1 ± 13.6） kPa, （42. 3 ± 20. O） kPa and （54. 5 ± 16.2） kPa, respectively. Significant difference was found among the groups （P 〈0. 001 ） and also between any two groups （P 〈 0.05 ）. ROC curve for the diagnosis of with vs. without OV, 〈 moderate vs. 〉 moderate OV, and 〈 severe vs. severe OV were 0. 798 （95% CI： 73.1% -86. 5% ） , 0. 823 （95% CI： 74.5 % -90. 0% ）and 0. 879 （95 % CI： 80. 8 % -95.0% ） , respectively, with corresponding FS cut-off value of 23.3 kPa, 31.5 kPa and 34.6 kPa. Conclusion Liver stiffness measurement allows to predict the sizes of oesophageal varices in patients with HBV-related cirrhosis.

关 键 词：肝炎 乙型 肝硬化 食管和胃静脉曲张 诊断 

分 类 号：R575.2[医药卫生—消化系统]