急性脑梗死患者血清胱抑素C水平与房颤的相关性  

The study on the relationship between the level of serum CysC and atrial fibrillation in patients with acute cerebral infarction

作　　者：刘萍[1] 罗本燕[1] 张筱英[1] 

机构地区：[1]浙江大学医学院附属第一医院神经内科,杭州310003

出　　处：《中国神经精神疾病杂志》2012年第12期720-723,共4页Chinese Journal of Nervous and Mental Diseases

基　　金：脑血管病康复规范化方案的研究.国家科技支撑计划(编号:2006BA101A14)

摘　　要：目的探讨脑梗死患者急性期血清胱抑素C(cystatin C,CysC)水平与房颤的相关性。方法 253例住院治疗的急性脑梗死患者被分为合并房颤组(n=40)及非合并房颤组(n=213),比较两组血清CysC、估算的肾小球滤过率(estimated glomerular filtration rate,eGFR)、血清肌酐(serum creatinine,Scr)、超敏C反应蛋白(hypersensitive C-reactive protein,hsCRP)、血脂、美国国立卫生研究院卒中量表(NIHSS)评分、Barthel指数(BI)的差异并分析CysC与房颤的相关性。结果急性脑梗死合并房颤组血清CysC(1.05±0.33 vs.0.84±0.19)、hsCRP[12(4.60-22.95)vs.4.6(1.1～13.25)]、NIHSS(8.56±7.29 vs.4.44±3.51)显著高于非合并房颤组(P<0.05),而TG(1.08±0.36 vs.1.57±0.80)、BI(31.6±28.2 vs.56.4±34.7)显著低于非合并房颤组(P<0.05)。CysC与年龄、既往卒中史、糖尿病、房颤、eGFR、Scr、TG均显著相关(P<0.05),校正上述因素后,CysC与房颤的相关系数为0.435(P=0.04)。多因素Logistic回归分析显示CysC的回归系数为2.386(OR=10.87,P=0.02)。结论急性脑梗死患者高血清CysC水平与房颤相关。Objective To investigate the relationship between the level of serum cystatin C （CysC） and atrial fibrillation （AF） in patients with acute cerebral infarction （ACI）. Methods Two hundred fifty-three patients with a- cute cerebral infarction were divided into ACI with AF group （n = 40） and ACI without AF group （n = 213）. The CysC, estimated glomerular filtration rate （eGFR）, serum creatinine （Scr）, hypersensitive C-reactive protein （hsCRP）, NIHSS, Barthel index （BI） were compared between the two groups. The relationship between serum CysC and AF was then analyzed. Results The serum CysC （ACI with vs without AF, 1.05 ± 0.33 vs. 0.84 ± 0.19）, hsCRP [ACI with vs. without AF, 12（4.60-22.95） vs. 4.6 （1.1-13.05）] and NIHSS （ACI with vs. without AF, 8.56 ± 7.29 vs. 4.44 ± 3.51 ） in the acute cerebral infarction with AF were significantly higher than those of patients without AF. the levels of TG （ACI with vs without AF, 1.08 ± 0.36 vs. 1.57 ± 0.80） and BI （ACI with vs without AF, 31.6 ± 28.2 vs. 56.4 ±34.7） were lower （P 〈 0.05）. There were marked correlations of CysC with age, the past history of stroke, diabetes mellitus, AF, eGFR, Scr, and TG （P 〈 0.05）. After adjusting for these factors, the correlation coefficient between serum CysC level and the prevalence of AF was 0.435 （P = 0.04）. Multivariable logis- tic regression showed regression coefficient was 2.386 （OR = 10.87, P = 0.02）. Conclusions High level of serum CysC is correlated with atrial fibrillation in patients with acute cerebral infarction.

关 键 词：急性脑梗死 胱抑素C 房颤 

分 类 号：R743.33[医药卫生—神经病学与精神病学]