吸烟与脑胶质瘤关系的Meta分析  

Meta-analysis of the association between smoking and glioma

作　　者：王洪建[1] 杨帆[1] 盖亚[1] 

机构地区：[1]滕州市中心人民医院肿瘤科,山东滕州277500

出　　处：《中华肿瘤防治杂志》2012年第24期1848-1851,共4页Chinese Journal of Cancer Prevention and Treatment

摘　　要：目的:评价吸烟与脑胶质瘤发生危险的关系。方法:检索1985-01-2012-10公开发表在Medline、EMBASE、Ovid和CNKI关于吸烟与脑胶质瘤发生关系的队列研究和病例对照研究。应用STATA 11.0统计软件分析吸烟与脑胶质瘤间的关联,计算合并优势比OR及95%可信区间(95%CI)。结果:最终共有12项研究纳入分析,其中队列研究4项,病例对照研究8项。Meta分析结果显示,各研究间不存在统计学异质性,I2=10.5,P=0.35。因此,合并分析采用固定效应模型。脑胶质瘤组与对照组人群中吸烟人数的优势比差异无统计学意义,OR=1.03,95%CI:0.95～1.11,P=0.53。亚组分析显示,分别以研究类型(队列研究/病例对照研究)、对照人群来源和研究种族为亚组进行分析,吸烟与脑胶质瘤发生无关,P>0.05。结论:吸烟与脑胶质瘤无明显相关性,烟草消费可能不是脑胶质瘤发生的危险因素。OBJECTIVE： To evaluate the relationship between smoking and glioma risk. METHODS： By searching Medline, EMBSE,Ovid and CNKI databases, the open published studies about the association between smoking and glioma risk from 1985-01 to 2012-10 were reviewed. The pooled odds ratio（OR） and 95% confidence interval of smokers in glio- ma patients compared to normal controls were aggregated by statistic software Statal 1.0. RESULTS：Twelve articles,with 8 case-control and 4 cohort studies,were included in this Meta-analysis. The heterogeneity test demonstrate that no statis- tical heterogeneity across studies was found（I2 = 10.5, P= 0.35）. The aggregated results showed there was no difference of the prevalence of smokers in glioma patients and normal controls （OR= 1.03,95 % CI： 0.95- 1. 11, P = 0. 53）. Sub- group analysis showed that no significant association between glioma and smoking in the subgroup analysis of study type, control type and different race （P〉0.05）. CONCLUSION： No close association between smoking and glioma risk is found in this Meta-analysis,whicb indicates smoking may not contribute to the incidence of glioma.

关 键 词：脑肿瘤 神经胶质瘤 诊断 吸烟 META分析 

分 类 号：R739.4[医药卫生—肿瘤]