血锂浓度监测在双相情感障碍患者治疗中的价值  

Prognosis value of the serum concentration monitoring of lithium in the treatment of blpolar disorder

作　　者：岳乔红[1] 周铁成[1] 程晓东[1] 童开[1] 胡娟娟[1] 郝晓柯[1] 

机构地区：[1]第四军医大学西京医院,710032

出　　处：《实用医技杂志》2013年第1期5-6,共2页Journal of Practical Medical Techniques

摘　　要：目的探讨碳酸锂治疗双相情感障碍患者的血清碳酸锂浓度与疗效关系。方法采用干化学方法对69例双相情感障碍性精神分裂症患者治疗过程中进行血锂浓度测定,用临床疗效总评量表、贝克-拉范森躁狂量表和简明精神病量表作为评定工具,分析患者血锂浓度与疾病疗效的关系。结果锂盐治疗双相情感障碍患者,通过调节服用锂盐的剂量,到第1周末,血锂浓度维持在一个相对稳定的水平;第3-5周末患者的临床症状得到有效控制,治疗前后疗效比较差异有统计学意义(P<0.05)。结论双相情感障碍性精神分裂症患者的治疗效果与血清锂浓度有一定的相关性,进一步分析其中的规律,有利于避免药物中毒,提高临床疗效。Objective To explore the relationship of efficacy and the lithium concentration of patients with bipolar disorder. Methods The serum lithium concentration of 69 patients with bipolar disorder were measured by dry chemical analysis. The efficacy were assessed by clinical general impression-severity （CGI-S）, beck-rafaelsen mania scale （BRMS）, brief psychosis rating scale （BPRS）. Results The serum lithium concentration maintained constant level at the end of the first week. The sympotoms of patients were controlled effectively, the score of CGI-S, BRMS, BPRS reduced significantly to the end of week 3 and week 5. There was significant difference （P〈O.05）. Conclusion The efficacy of patients with bipolar disorder is correlated with serum lithium concentration. Employing this mechanism is favorable to avoid the possible toxic adverse events and guarantees the safety of drugs.

关 键 词：药物监测 双相情感障碍 治疗应用 

分 类 号：R749.4[医药卫生—神经病学与精神病学]