若干生物学指标对淋巴结阴性乳腺癌预后意义的评价  

Evaluation of several biological markers in the prognosis of patients with node negative breast cancer

作　　者：张斌[1] 李艳萍[1] 马特[1] 邹俊芝[2] 董卫[3] 张强[1] 赵林[1] 

机构地区：[1]辽宁省肿瘤医院乳腺科,沈阳110042 [2]辽宁省肿瘤医院病理科,沈阳110042 [3]中国医科大学流行病室

出　　处：《中华肿瘤杂志》2000年第4期298-300,共3页Chinese Journal of Oncology

摘　　要：目的　综合评估C erbB 2、CD44V6、nm2 3、组织蛋白酶D(cath D)的表达 ,肿瘤微血管计数 (MVC)及常用临床病理指标对淋巴结阴性乳腺癌患者的预后意义。方法　对 6 2例单纯采用手术治疗并随访 10年以上的淋巴结阴性侵袭性乳腺癌石蜡包埋标本 ,用免疫组化S P法检测C erbB 2、CD44V6、nm2 3、cath D表达 ,肿瘤微血管计数及其他临床病理指标 ,并与患者 10年生存率关系进行单因素和多因素分析。结果　单因素分析表明 ,影响患者 10年生存率的因素为MVC、C erbB 2、肿瘤间质cath D和CD44V6 (P <0 0 0 1,P <0 0 1,P <0 0 1和P <0 0 5 )。多因素分析表明 ,仅MVC是影响患者生存率的独立预后因素。结论　MVC、C erbB 2、间质cath D和CD44对淋巴结阴性侵袭性乳腺癌患者预后有重要意义 。Objective To evaluate the practical significance of microvessel count (MVC), c erbB 2, CD44, cathepsin D and nm23 expression, and clinico pathological parameters in the prognosis of node negative breast cancer. Methods Sixty two patients with node negative invasive breast cancer were treated by surgery alone, and followed up for at least 10 years. Microvessel count (MVC), C erbB 2, CD44, Cathepsin D and nm23 expression were studied by immunohistochemical technique. With other clinico pathological parameters, they were evaluated prognostically. Results Univariate analysis showed that the prognostic factors influencing 10 year overall survival rate were MVC, C erbB 2, stromal cell cath D and CD44 expression. Multivariate analysis demonstrated that MVC was the sole independent prognostic factor determining 10 year survival. Conclusion Although MVC, c erbB 2, stromal cell cath D and CD44 expression are all of prognostic significance, MVC is most meaningful in evaluating prognosis of node negative breast cancer patients.

关 键 词：乳腺肿瘤 淋巴转移 C-ERBB-2表达 CD44表达 预后 

分 类 号：R737.9[医药卫生—肿瘤]