小细胞肺癌预防性脑照射的临床研究  

Clinical study of prophylactic cranial irradiation for small-cell lung cancer

作　　者：曹卡加[1] 黄惠英[1] 涂明耻[1] 潘国英[1] 

机构地区：[1]广州中山医科大学肿瘤防治中心放疗科,510060

出　　处：《中华肿瘤杂志》2000年第4期336-338,共3页Chinese Journal of Oncology

摘　　要：目的　探讨预防性全脑照射 (PCI)对局限期小细胞肺癌 (SCLC)脑转移率和生存率的影响。方法　 1990年 1月～ 1995年 12月间 ,5 1例经化疗加放疗后完全缓解的局限期SCLC患者被随机分为脑照射组 (2 6例 )和对照组 (2 5例 )。脑照射组患者接受PCI 2 5 2～ 30 6Gy。结果　脑照射组患者的脑转移率为 3 8% ,明显低于对照组的 2 8 0 % (P <0 0 5 )。脑照射组患者的 1,2 ,3年生存率分别为 84 6 % ,73 1%和 42 3 % ,对照组分别为 72 0 %、40 0 %和 32 0 % ,两组比较差异无显著性 (P >0 0 5 )。脑照射组患者未出现严重放射后遗症。结论　预防性全脑照射能减少局限期SCLC的脑转移 。Objective To study the influence of prophylactic cranial irradiation (PCI) on survival and brain metastases in patients with limited small cell lung cancer (SCLC).Methods Fiftyone patients with limited SCLC under complete remission after chemoradiotherapy were randomly divided into prophylactic cranial irradiation (PCI) group ( n =26) and control group ( n =25). Patients in PCI group received irradiation at a dose of 25.2～30.6 Gy. Survival rates were analyzed and compared by life table and Long Rank, incidence of cranial metastases by χ 2 test.Results The clinical features of patients such as age, sex, effect of treatment before PCI were similar between the two groups. The incidence of cranial metastases was 3.8% in PCI group in contrast to 28% in the control group ( P <0.05). The 1, 2, 3 year survival rate was 84.6%, 73.1%, 42.3% respectively in PCI group and 72%, 40%, 32% respectively in the control group. The differences between the two groups of petients were statistically insignificant. No serious sequela was observed in patients receiving PCI.Conclusion PCI decreases the incidence of cranial metastases for patients with limited SCLC following complete response to chemoradiotherapy, but it does not improve survival.

关 键 词：肺肿瘤 小细胞肺癌 放射疗法 药物疗法 

分 类 号：R734.2[医药卫生—肿瘤]