地佐辛与吗啡治疗晚期癌痛效果比较  

Comparison of dezocine with morphine for relief of pain for late cancer

作　　者：章明[1] 严英[1] 劳惠丽[1] 

机构地区：[1]绍兴第二医院麻醉科,绍兴321000

出　　处：《中国药物滥用防治杂志》2012年第5期266-268,共3页Chinese Journal of Drug Abuse Prevention and Treatment

摘　　要：目的:比较地佐辛与吗啡治疗晚期癌痛的疗效,为临床合理用药提供依据。方法:将80例伴有中重度疼痛的晚期癌症住院患者随机分为两组,每组40人,对照组给与肌内注射10mg地佐辛,观察组给与肌内注射吗啡10mg,两组给药均为每6小时一次,持续1周,观察期间两组疼痛程度、疼痛缓解度以及不良反应。结果:地佐辛和吗啡均产生明显的镇痛效果;但地佐辛效果优于吗啡,地佐辛不良反应发生率低于吗啡。结论:地佐辛镇痛效果与吗啡相近,不良反应较轻,是一个疗效显著、安全便利的镇痛药。Objective：to compare dezocine with morphine for pain relief for late cancer. Methods： 60 hospitalized subjects with moderate to severe pain as a result of advanced cancer were randomized into dezocine group （n=40） and morphine group （n=40）. The dezocine group were treated with 10mg dezocine while morphine group with 10mg morphine every 6 hours. During 7-day treatment, pain intensity, pain relief and negative effects were recorded. Results： Both the two groups got marked pain relief; but dezocine had better effect than morphine ;total adverse reaction incidence rate in dezocine group was obviously lower than morphine group. Conclusion： Dezocine is as effect as morphine in pain relief and has lower rate of adverse reaction incidence. It is effective, safe and convenient.

关 键 词：地佐辛 吗啡 晚期癌症 镇痛 

分 类 号：R730.5[医药卫生—肿瘤]