139例肺腺鳞癌的预后因素分析  

The analysis of factors prognostics of 139 patients with adenosquamous carcinoma of the lung

作　　者：刘智华[1] 潘纯国[1] 徐建华[1] 钟军[1] 

机构地区：[1]江西省肿瘤医院放疗中心,330029

出　　处：《中国实用医药》2012年第35期7-10,共4页China Practical Medicine

摘　　要：目的探讨肺腺鳞癌临床病理特点及预后因素。方法对139例肺腺鳞癌患者的临床资料进行回顾性分析。选择性别、年龄、自然病程、病理T分期、病理N分期、病理M分期,病理TMN分期、手术方式、术后放疗、术后辅助化疗等因素进行预后分析。统计分析运用SPSS12.0软件行Log-rank检验和Cox模型多因素分析。结果本组肺腺鳞癌的5年生存率分别为21.6%,手术治疗组的5年生存率为23.6%。Log-rank检验显示、N分期、M分期、病理TMN分期、手术方式、术后放疗及术后化疗对预后有显著影响(P<0.05)。经Cox多因素分析结果表明仅有病理TMN分期对预后有显著影响;辅助化疗明显改善生存。结论肺腺鳞癌是一种生物学行为恶性程度较高的非小细胞肺癌,单纯外科治疗效果差,需积极联合辅助化疗。Objective Study clinicopathologic characteristics and prognosis of adenosquamouscarci- noma of the lung. Methods The study group consisted of 139 patients of adenosquamouscarcinoma. The prog- nostic univariate analyse and multivariable analysis were performed by these factors which including sex, age, course of disease, T stage, N stage, M stage, UICC pathologic TNM staging, the method of operation, postopera- tive chemotherapy or radiotherapy. The analyse was calcuted by the soft SPSS 12. 0. Results The overall sur- vival rate at 5year was 2l. 6 % and 23.6%, respectively in the all cases and the group resection. According to the result of univariate analyse, it showed that T stage, N stage, M stage, UICC pathologic TNM staging, the method of operation, postoperative chemotherapy or radiotherapy were all factors prognostics. But the Cox prog- nostic multivariate analysis proved that UICC pathologic TNM staging and postoperative chemotherapy were the most important factors prognostics. Conclusion The lung adenosquamous carcinoma is a highly aggressive non- small lung cancer with a dissatisfactory result by single surgical treatment, the adjuvant chemotherapy was jointed with the resection necessarily.

关 键 词：肺肿瘤 腺鳞癌 辅助化疗 预后 

分 类 号：R734.2[医药卫生—肿瘤]