Endoglin表达和MVD检测与肺癌凋亡指数及临床病理特性相关研究  

The expression of Endoglin and MVD detection and lung cancer apoptosis index and clinical pathological characteristics research

作　　者：杜志强[1] 李宇清[1] 秦建勇[1] 

机构地区：[1]广州医学院第二附属医院肿瘤科,510260

出　　处：《中国实用医药》2012年第35期21-22,共2页China Practical Medicine

摘　　要：目的探究肺癌组织中Endoglin表达和微血管密度(MVD)与凋亡指数和临床病理特性之间的相关性。方法回顾性对照研究我院行肺癌根治手术后随访大于5年且临床资料完整的60例肺癌患者的临床资料,根据患者的生存时间分为三组,生存时间≥5年者为A组、生存时间3～5年者为B组,生存时间<5年者为C组,分别研究肺癌组织Endoglin的表达、MVD计数、凋亡指数(AI)与肿瘤病理、分期、预后、凋亡指数间的关系。结果 A组患者的MVD记数平均为(26.32±8.49),平均术后生存期为(6.5±1.3)年,与B、C组相比,均具有统计学意义(P均<0.05);A、B、C组凋亡分数(AI)分别为(5.67±3.11)%、(8.49±3.42)%、(16.57±2.68)%,三组间两两比较,均具有统计学意义(P均<0.05)。结论肺癌中的Endoglin表达和MVD记数与肺癌的凋亡指数密切相关,且MVD记数越高,凋亡指数越高,肿瘤恶性程度越高,预后越差。Objective To investigate the expression of Endoglin in lung cancer tissue and microvessel density （MVD） and apoptosis index and clinical pathological characteristics of the correlation between. Meth- ods A retrospective case-control study of lung cancer radical operation line followed up for more than 5 years and complete clinical data of 60 cases of lung cancer patients with the clinical data, according to the survival time of patients were divided into three groups, the survival time was more than five years for the A group, the survival time ranged from three to five years for the B group, the survival time 〈 five years for the C group, re- spectively study of lung tissue Endoglin expression, MVD counts, apoptosis index （AI） and tumor pathology, staging, prognosis, apoptosis index relation. Results In group A MVD notation for an average of （26.32 ± 8.49）, the average postoperative survival time was （6. 5 ± 1.3 ） y, and B, compared with C group, P 〈 0.05, with statistically significant. A, B, C group of apoptotie scores （AI） were （5.67 ± 3.11）%, （8.49 ±3.42）% ,（16.57 ±2.68）%, three group with statistically signifieant（P 〈0.05）. Conclusion The expres- sion of Endoglin in lung cancer and MVD counting and lung cancer is closely related to the apoptosis index, and MVD counting is higher, the apoptotic index is higher, the malignant degree is higher, the worse the prognosis.

关 键 词：肺癌 Endoglin表达 MVD记数 凋亡指数 

分 类 号：R734.2[医药卫生—肿瘤]