不同致伤时间所致大鼠深Ⅱ度烫伤创面自然愈合的病理学观察  

Pathological Observation on Wound Healing of Deep Partial Thickness Burn in Rats by Scalding with Different Length of Time

作　　者：王莉[1] 严忠馥[1] 冯世杰[1] 方培耀[1] 郭寿延 王宝美[1] 

机构地区：[1]上海第二医科大学,病理学教研室上海200025

出　　处：《上海实验动物科学》2000年第2期79-81,共3页Shanghai Laboratory Animal Science

基　　金：国家自然科学基金重大项目!(39290700-5)

摘　　要：为了探讨深 度烫伤的愈合机理 ,采用 80℃ 6 s和 1 5 s水烫 SD大鼠皮肤制备致深 度烫伤的动物模型 ,定期光镜观察创面自然愈合的情况。结果表明 6 s烫伤组的局部微循环障碍程度较轻 ,烫后 7d真皮深部残留毛囊上皮增生并覆盖创面 ,烫后 1 4d创面已基本愈合。1 5 s烫伤组的局部微循环障碍明显 ,烫后 7d创面进行性加深 ,由深 度向 度演变 ,烫后 1 4d痂下脓肿形成 ,创面未能愈合。结果提示 ,微循环障碍程度与致伤时间密切相关 。To explore the mechanisms in wound-healing of deep partial thickness burns of skin, an animal model was prepared by scalding SD rat skin with water at 80℃for 6 and 15 seconds in group 1 and 2 respectively, and then followed by light microscopic observation on the natural healing of the wound at fixed intervals. The local microcirculatory impairement of the rats in group 1 was found less serious, 7 days after the scald proliferation of the epithelium of hair follicles, which remained deep in the corium, took place and covering the wound surfaces, and 14 days after the scald the wounds were almost healed. In group 2, the microcirculatory impairement was so obvious .Seven 7 days after scald the wound showedwere deepening progressively from deep partial to full thickness burns, another week later abscess formed beneath the scabs that hindered the wound from healing. It is concluded that the degree of impairement of microcirculation is highly correlated with the length of time of scalding.The severity of microcirculatory impairement and the inflammatory reaction beneath the scabs are both major factors that affect the wound healing.

关 键 词：大鼠 烫伤 创面愈合 病理学 深Ⅱ度 致伤时间 

分 类 号：R361.2[医药卫生—病理学]