抗抑郁药物对抑郁症患者血清细胞因子的影响  

The effect of antidepressive drugs on serum level of cytokines in depressive patients

作　　者：田博[1] 刘彬[1] 

机构地区：[1]山东省青岛市精神卫生中心,266034

出　　处：《精神医学杂志》2012年第6期430-431,共2页Journal of Psychiatry

基　　金：青岛市卫生局立项课题(编号:2008-WSZD108)

摘　　要：目的探讨抗抑郁药物对抑郁症患者血清细胞因子的影响。方法将90例抑郁症患者随机分为氟西汀组和马普替林组各45例,分别给予氟西汀和马普替林治疗8周,在治疗前后应用ELISA方法检测患者血清细胞因子(IL-6,TNF-α)水平,并采用药物副反应量表(TESS)评估药物副反应。结果氟西汀组和马普替林组治疗后IL-6和TNF-α含量均较治疗前有所下降(P<0.05,P<0.01),并且氟西汀组较马普替林组能明显降低血清中IL-6、TNF-α含量(P<0.05),氟西汀组副反应较马普替林组少(P<0.05)。结论抑郁症与血清IL-6和TNF-α水平升高有关,而抗抑郁药物能降低血清前炎症细胞因子含量,并且氟西汀的免疫调节作用较马普替林有优势。Objective To investigate the effect of antidepressive drugs on serum level ot cytokmes in Oepress^ve patients. Methods 90 depressive patients were randomly divided into maprotiline group （45 cases） and iluoxetine group （45 cases） treated with maprotiline and fluoxetine respectively for 8 weeks. The serum levels of IL-6 and TNF-a were detected by Enzyme-linked Immunosorbent Assay （ELISA） at baseline and at the end of the treatment. Side effects were evaluated with Treatment Emergent Symptom Scale （TESS）. Results The post-therapy serum levels of IL-6 and TNF-a in fluoxetine group and maprotiline group decreased significantly when compared with baseline （ P 〈 0. 05, P 〈 0.01 ）. The levels of IL-6 and TNF-a in fluoxetine group were significantly lower than those in maprotiline group at the endpoint（P 〈 0. 05 ）. The side effects in fluoxetine group were fewer than that in maprotiline group （P 〈 0. 05 ）. Conclusion Depression is associated with the high level of IL-6 and TNF-a. Antidepressive drugs can suppress serum level of inflamatory. The efficiency of immunoregulation of fluoxetine is better than that of maprotiline in the treatment of depression.

关 键 词：抑郁症 细胞因子 马普替林 氟西汀 

分 类 号：R749.4[医药卫生—神经病学与精神病学]