应用动脉自旋标记技术分析阿尔茨海默病脑血流灌注成像的研究  

Application of arterial spin labeling technique in cerebral perfusion imaging of patients with Alzheimer disease

作　　者：张世娟[1] 王志群[2] 梁佩鹏[2] 赵志莲[2] 卢洁[2] 

机构地区：[1]首都医科大学宣武医院综合内科,北京100053 [2]首都医科大学宣武医院放射科,北京100053

出　　处：《中华老年心脑血管病杂志》2013年第1期35-38,共4页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

基　　金：国家自然科学基金(81000606;30900365)

摘　　要：目的应用脉冲动脉自旋标记技术,分析阿尔茨海默病(AD)患者脑血流灌注的改变情况。方法采集静息状态下17例AD患者(AD组)及17例健康志愿者(对照组)动脉自旋标记的灌注成像数据,计算其相对脑血流量。结果与对照组比较,AD组患者双侧颞叶、左侧额叶、双侧顶叶、双侧枕叶及左侧丘脑的相对脑血流量均有下降。结论动脉自旋标记的灌注成像为检测AD患者异常灌注改变提供了一种有价值的方法,AD患者的低灌注与其脑结构和功能的改变密切相关。Objective To study the application of pulsed arterial spin labeling（PASL） technique in cerebral perfusion of patients with Alzheimer＇s disease（AD）. Methods Cerebral perfusion ima ging data of PASL were collected from 17 AD patients（AD group） and 17 healthy volunteers（control group）. Relative cerebral blood flow（rCBF） in two groups was measured. Results The rCBF in bilateral temporal lobe,left frontal lobe, bilateral parietal lobe, occipital lobe and left thalamus was lower in AD group than in control group. Conclusion PASL perfusion imaging is avaluable method for detecting the abnormal perfusion changes in AD patients and hypoperfusion is closely related with the structural and functional changes in their brain.

关 键 词：阿尔茨海默病 自旋标记物 血液灌注 磁共振成像 

分 类 号：R749.16[医药卫生—神经病学与精神病学]