In vivo Anticancer Activities of Benzophenone Semicarbazone against Ehrlich Ascites Carcinoma Cells in Swiss Albino Mice  

作　　者：Khairul Islam Shaikh M Mohsin Ali Mele Jesmin Jahan Ara Khanam 

机构地区：[1]Department of Applied Chemistry and Chemical Engineering,University of Rajshahi,Rajshahi 6205,Bangladesh [2]Department of Biochemistry and Molecular Biology,University of Rajshahi,Rajshahi 6205,Bangladesh

出　　处：《Clinical oncology and cancer researeh》2012年第4期242-247,共6页

基　　金：supported by a grant from the National Science and Information and Communication Technology of Bangladesh

摘　　要：Objective Benzophenone semicarbazone(BSC) was synthesized and characterized to identify compounds with anticancer activities. Methods Anticancer activities were studied against Ehrlich Ascites Carcinoma(EAC) cells in Swiss albino mice by monitoring parameters such as tumor weight measurement,survival time of tumor bearing mice,tumor cell growth inhibition,and so on.Some hematological parameters,such as red blood cells,white blood cells,and hemoglobin content,were also measured. Results The results showed that BSC has a positive effect against EAC cells.An assessment was conducted by comparing these results with those obtained using the standard drug bleomycin. Conclusions The BSC compound can be considered as a potent anticancer agent.Objective Benzophenone semicarbazone （BSC） was synthesized and characterized to identify compounds with anticancer activities. Methods Anticancer activities were studied against Ehrlich Ascites Carcinoma （EAC） cells in Swiss albino mice by monitoring parameters such as tumor weight measurement, survival time of tumor bearing mice, tumor cell growth inhibition, and so on. Some hematological parameters, such as red blood cells, white blood cells, and hemoglobin content, were also measured. Results The results showed that BSC has a positive effect against EAC cells. An assessment was conducted by comparing these results with those obtained using the standard drug bleomycin. Conclusions The BSC compound can be considered as a potent anticancer agent.

关 键 词：anticancer activities EAC cell benzophenone semicarbazone 

分 类 号：R73-3[医药卫生—肿瘤]