侵袭性牙周炎患者血浆瘦蛋白水平与牙周临床指标的相关性研究  

Association between plasma leptin level and periodontal parameters in patients with aggressive periodontitis

作　　者：刘蕴玉[1] 张欣[1] 释栋[1] 陈智滨[1] 孟焕新[1] 

机构地区：[1]北京大学口腔医学院·口腔医院牙周科,100081

出　　处：《中华口腔医学杂志》2013年第1期3-6,共4页Chinese Journal of Stomatology

基　　金：国家自然科学基金（30973319）;“十一五”国家科技支撑计划（2007BA118802）;卫生部部署（管）医院2010-2012年度临床学科重点项目

摘　　要：目的研究侵袭性牙周炎患者血浆瘦蛋白水平及其与牙周临床指标之间的相关性，以期为临床提供参考。方法选择97例侵袭性牙周炎患者和44名牙周健康对照者，记录受试者的出血指数（bleeding Index，BI）、探诊深度（probing depth，PD）、附着丧失（attachment loss，AL）等牙周临床指标；抽取受试者空腹外周静脉血，应用酶联免疫吸附测定法检测血浆瘦蛋白水平。结果侵袭性牙周炎患者的血浆瘦蛋白水平[（20．0±4．3）μg/L]显著高于健康对照者[（7．5±1．3）μg／L]，P〈0．01。在所有受试者中，血浆瘦蛋白水平与BI、PD、AL等指标均呈显著的正相关关系，r值分别为0．647、0．596和0．632，P〈0．01。结论侵袭性牙周炎患者的血浆瘦蛋白水平升高，血浆瘦蛋白水平与BI、PD、AL等指标呈正相关关系。Objective To detect the plasma leptin levels in patients with aggressive pefiodontitis （AgP） and to analyze the relationship between circulating leptin level and periodontal condition. Methods A total of 97 patients with AgP and 44 healthy controls were recruited. Detailed clinical examinations were conducted and clinical parameters such as bleeding index （ BI ） , probing depth （ PD ）, attachment loss（AL） were recorded. Plasma leptin level was measured by enzyme-linked immunosorbnent assay. Results The plasma leptin level in AgP group was significantly higher than that of control subjects [ （20. 0 ±4. 3） μg/L vs. （7.5 ± 1.3） μg/L,P 〈0. O1 ） ]. The plasma leptin level was positively related to BI, PD and AL, and the r values were 0.647, 0.596 and 0.632 respectively （P〈O. 01）. Conclusions Plasma leptin concentration in AgP patients was significantly elevated compared with healthy controls. Circulating leptin level was positively related to periodontal parameters including BI, PD and AL.

关 键 词：侵袭性牙周炎 瘦蛋白 附着丧失 

分 类 号：R781.4[医药卫生—口腔医学]