ERCC-1和RRM-1在非小细胞肺癌组织中的表达及病理的临床分析  

Expression of ERCC-1 and RRM-1 in non-small cell lung cancer tissues and the clinical analysis

作　　者：陈伟文[1] 王志刚[1] 沈冰寒[1] 郭伟峰[1] 叶晓艺[1] 郑锦阳[2] 

机构地区：[1]福建医科大学附属泉州市第一医院呼吸内科,福建泉州362000 [2]福建医科大学附属泉州市第一医院病理科,福建泉州362000

出　　处：《临床肺科杂志》2013年第2期215-216,共2页Journal of Clinical Pulmonary Medicine

摘　　要：目的研究切除修复交叉互补基因ERCC1、核苷酸还原酶调节因子RRM1在非小细胞肺癌中的表达及其临床价值。方法选择非小细胞肺癌患者作为观察组,肺部良性病变患者作为良性对照组、体检者作为健康对照组,采用SurPlexTM液相芯片技术检测肺癌组织中ERCC1、RRM1的mRNA相对含量。结果观察组患者肺癌组织中ERCC1、RRM1的mRNA含量明显高于良性病变对照组和健康对照组,且呈现出TNMⅠ<TNMⅡ<TNMⅢ<TNMⅣ的趋势。结论肺癌组织中ERCC1和RRM1的mRNA含量明显高于良性病变和健康组织,对疾病有一定的诊断意义。Objective To study the expression of ERCC-1 and RRM-1 in non-small cell lung cancer tissues and its clinical value. Methods non-small cell lung cancer patients as the observation group, benign lung lesions patients as benign control group, physical examination subjects as healthy control group, using SurPlexTM liquid chip technology to detect ERCC1 and RRM1 mRNA content in lung tissue. Results ERCC1, RRM1 mRNA content of observation group were significantly higher than benign and healthy control group, showing TNM I 〈 TNM Ⅱ 〈 TNMm 〈 TNMIV. Conclusion ERCC1 and RRM1 mRNA content in lung cancer was higher than benign lesions and healthy tissue and has a certain significance in the diagnosis.

关 键 词：非小细胞肺癌 DNA修复 切除修复交叉互补基因1 核苷酸还原酶调节因子 

分 类 号：R734.2[医药卫生—肿瘤]