人类子宫内膜容受性评估的研究进展  

Advance of endometrium receptivity evaluated in human

作　　者：徐少元[1] 刘倍余[1] 李洁[1] 

机构地区：[1]中山大学附属第一医院生殖医学中心,广州市510080

出　　处：《生殖医学杂志》2013年第1期19-23,共5页Journal of Reproductive Medicine

基　　金：广东省科技计划项目(2009B030801022);国家自然科学基金(2008-30872762)

摘　　要：人类胚胎着床是一个复杂的程序化过程,涉及众多生物机制参与。其中胚胎质量与发育潜能和子宫内膜对胚胎容受性是影响着床成功的两个最重要因素。尽管现行辅助生殖技术在不孕不育症的治疗中已经取得了巨大进步,人们能够根据胚胎形态学选择具有发育潜能的胚胎进行移植,体外培养第3天和第5天胚胎种植率分别达到25%～35%,但是大约占移植数目2/3的胚胎丢失仍然是目前限制体外受精(IVF)成功的重要原因。The endometrium is one of the most fascinating tissues in the human body. Embryo im- plantation is a process that requires both temporal and spatial synchronization of the uterine endometrium and the embryo, and endometrium becomes receptive to the embryo during the window of implantation. Morphofunctional changes including sonography phenotype ~ pinopode, estrogen receptor（ER） and progesto- gen receptor（PR）expressi0n in endometrial biopsy during this period may prevent or hinder the implanta- tion. The expression patterns of many implantation-related molecules（such as integrin av133, LIF, EGF, VEGF,ICAM-1,NO et al）change dynamically during this process. It becomes clear that overcoming the current bottleneck in improvements to assisted reproductive techniques will require a closer look at biomar- ker in the interface between uterus and embryo. Indeed,embryo implantation requires a cross talk with a receptive endometrium. We Can learn more molecular markers related anatomical and functional of endome- trial receptivity from the genomies and proteomics. This article reviews the potential marker which might be reflecting of endometrial receptivity.

关 键 词：子宫内膜容受性 着床 胞饮突 基因组学 蛋白质组学 

分 类 号：R[医药卫生]