选择性单囊胚移植与双卵裂胚移植的临床结局比较  

Comparison of clinical outcomes of elective single blastocyst transfer with double cleavage embryo transfer

作　　者：张波[1] 冯贵雪[1] 周红[1] 甘贤优[1] 伍芳蓉[1] 舒金辉[1] 

机构地区：[1]广西壮族自治区妇幼保健院生殖中心,南宁530003

出　　处：《生殖医学杂志》2013年第1期30-33,共4页Journal of Reproductive Medicine

基　　金：广西自然科学基金(桂科攻0897007;桂科自(0832183;0542058);广西卫生厅重点课题(重200947;2011063;2011065)

摘　　要：多胎妊娠被视为人类辅助生殖技术（assisted reproduc tivetechnology，ART）中的一种并发症、而不是成功的助孕结局。研究证实，降低多胎妊娠的最佳手段是单胚胎移植，而单囊胚移植的临床妊娠率明显高于单卵裂期胚胎移植。这提示囊胚可能是实现单胚胎移植的理想时期。Objective： To compare the clinical outcomes of elective single blastocyst transfer（SBT）with double cleavage embryo transfer（DET）. Methods： Patients with good prognosis and high risk of multiple pregnancy（treatment cycle2, aged 38years,day 3 high quality embryo3,and normal endometrium）were divided into SBT group and DET group according to their patients option. The implantation rate（IR）, clinical pregnancy rate（CPR）and multiple pregnancy rate（MPR）were compared between the two groups. Based on the above groundwork, we also compared the clinical outcomes of one SBT cycle plus one frozen cycle blastocyst transfer（FBT） （1SBT＋IFBT）with those of one DET plus one FBT（1DET＋IFBT）. Results： The IR in SBT group was significantly higher than that in DET group（52.4% vs. 43.4%, P^0.05） ,while the CPR（52.4% vs. 60.1% ,P^0. 05）was significantly lower in SBT group compared with DET group. However, patients in the SBT group had a significantly lower multiple pregnancy rate compared with DET group（P^0. 05）. There was no significant difference in the cumulative pregnancy rate between the 1SBT＋IFBT group and the 1DET＋IFBT group（76.8% vs. 80.4%,P〉0.05）,but the multiple pregnancy rate was significantly lower in the former（4. 9% vs. 37.8% ,P〈0.05）. Conclusion. The higher implantation rate with similar cumulative pregnancy rate is obtained in SBT group. The SBT is proposed to be an effective method for significantly reducing the risk of multiple pregnancies without compromising the clinical pregnancy rate.

关 键 词：单囊胚移植 双卵裂胚胎移植 种植率 临床妊娠率 多胎妊娠 

分 类 号：R[医药卫生]