前部巩膜厚度及相关眼部参数的研究  

The study of anterior sclera thickness and associated ocular parameters

作　　者：李梅[1] 才瑜[1] 潘英姿[1] 乔荣华[1] 方圆[1] 王捷[1] 

机构地区：[1]北京大学第一医院眼科 视觉损伤与修复教育部重点实验室,100034

出　　处：《中华实验眼科杂志》2013年第1期81-85,共5页Chinese Journal Of Experimental Ophthalmology

摘　　要：背景巩膜的活体测量对于了解巩膜本身的厚度及一些相关疾病均有较大帮助。目的观察年龄相关性白内障人群前部巩膜厚度及其与相关眼部参数间的关系。方法分别采用超声角膜测厚仪、角膜曲率仪及眼部A型超声对105例年龄相关性白内障患者进行双眼中央角膜厚度（CCT）、角膜屈光力（CCV）及眼轴长度测量，同时采用超声生物显微镜（UBM）测量颞侧巩膜突后2mm处的前部巩膜厚度（AST）。分别采用配对t检验及独立样本t检验对不同眼别、不同性别间的CCT、CCV、眼轴长度和AST参数进行比较；采用Pearson积矩线性相关分析法分析上述各参数间的相关性，并采用单因素方差分析比较不同眼轴长度患者CCT及AST的差异。结果受试者双眼间CCT、CCV、眼轴长度及AsT值的差异均无统计学意义（t=0．584，P=0．561；t=1．161，P=0．248；t=0．140，P=0．889；t=0．342，P=0．773）。男性组测量的平均CCT厚度值小于女性组，但差异无统计学意义（右眼：t=0．469，P=0．641；左眼：t=0．465，P=0．643）；与女性组比较，男性组的眼轴明显较长，平均CCV值明显降低，平均AST明显增厚，差异均有统计学意义（左右眼均P〈0．01）。本组受试者右眼颞侧巩膜突后2mm处AST为（0．59±0．05）mm。相关分析表明，CCV与眼轴长度呈显著负相关（r=-0．50，P〈0．01），但年龄、CCT、眼轴长度及AST间无明显相关性（P〉0．05）。不同眼轴长度组间受试者CCT和AST的差异无统计学意义（CCT：F=0．998，P=0．372；AST：F=1．919，P=0．383）。结论年龄相关性白内障患者的AST与CCT间无明显相关；一定程度的眼轴变长可能不伴随前部眼球壁的变薄；男女间眼部的部分参数可能存在一定差异。Background The condition of the selera is associated with many ocular diseases. The measurement of human scleral thickness in vivo is helpful for us to understand the features of the sclera and related diseases. Objective The present study was to measure the anterior sc]era thickness （AST）in patients with senile cataract and to analyze the relationship among AST and other associated ocular parameters. Methods This study was approved by the Ethic Commission of First Hospital of Peking University. Written informed consent was obtained from each individual prior to examination. One hundred and five senile cataract patients were recruited in this study. Central corneal thickness （CCT）, corneal curvature （CCV） and axial length were measured using ultrasonic pachymeter, keratometer, and A-scan unit, respectively. The AST was measured at 2 mm posterior to the scleral spur in the temporal meridian using ultrasound biomieroscope （UBM）. The differences of CCT, CCV, ocular axial length and AST between bilateral eyes and the different sexes were compared by the Paired test and independent sample t test. The correlations among various parameters were assessed by the Pearson linear correlation analysis. The differences of CCT and AST among different axial length groups were evaluated by one-way ANOVA. Results No significant differences were found in the CCT, C CV, axial length and AST between bilateral eyes （t = 0. 584, P = 0. 561 ;t = 1. 161 , P=0. 248;t=0. 140,P=0. 889;t=0. 342,P=0. 773）. Temporal AST at 2 mm posterior to the sclera spur was（0. 589± 0. 051 ）mm in the right eyes. An insignificant decline in CCT was found in the male group compared with the female group （ right eyes ： t = 0.469, P = 0.641 ; left eyes ： t = 0. 465, P = 0. 643 ）. However, compared with the female group, the increase of axial length, reduction of the mean CCV value and enhancement of the mean AST were observed （right eyes：all P〈 0. 01 ;left eyes：all P〈0.01 ）. CCV showed a negative correlation with ocul

关 键 词：生物学测量 巩膜厚度 中央角膜厚度 眼轴 超声生物显微镜 

分 类 号：R779.6[医药卫生—眼科]