脑胶质瘤瘤周水肿影响因素的相关研究  

Correlation of influencing factors with the extent of peritumoral brain glioma edema

作　　者：戎建东[1] 丁方[1] 李甲[1] 朱光耀[1] 何瞻[1] 

机构地区：[1]浙江省宁波市医疗中心李惠利医院神经外科,315040

出　　处：《中华医学杂志》2013年第3期169-171,共3页National Medical Journal of China

摘　　要：目的探讨脑胶质瘤瘤周水肿程度与患者一般情况及病情、病理之间的关系。方法对2010至2011年浙江省宁波市医疗中心李惠利医院69例手术后经病理证实为胶质瘤的患者进行分析，对可能促进瘤周水肿形成的性别、年龄、KPS评分、发病至就诊时间及肿瘤大小、部位、形状、病理分级进行逐步多元线性回归分析。结果69例均发生瘤周水肿，进入水肿指数回归方程的相关因素有肿瘤病理分级、发病至就诊时间、术前KPS分级及年龄，其偏回归系数依次为0．853、0．456、-0．352和0．291（P〈0．01）。结论脑胶质瘤瘤周水肿程度与患者病理分级、发病至就诊时间、术前KPS评分及年龄有关，号陛别、肿瘤大小、肿瘤部位及形状无关。Objective To explore the correlation of various influencing factors with the extent of peritumoral brain glioma edema. Methods A total of 69 glioma cases were confirmed by pathology after operation. And stepwise multiple linear regression analysis was performed on gender, age, Karnofsky performance scale （KPS） score, onset to treatment time, tumor size, location, shape and WHO pathological grade. Results All of them had peritumoral edema. The relevant factors included pathology grading, onset to treatment time, KPS score and age. The data were entered into the regression equation of edema index. The partial regression coefficients were 0. 853, 0. 456, -0. 352 and 0. 291 respectively （P 〈 0. 01 ）. Conclusion Peritumoral brain edema in glioma patients are correlated with WHO pathologic grading, onset to treatment time, KPS score and age. But it has no correlation with patient gender, tumor location, tumor size and shape.

关 键 词：胶质瘤 肿瘤周围水肿 水肿指数 病理分级 

分 类 号：R739.4[医药卫生—肿瘤]