乳腺浸润性导管癌的超声造影增强表现和血流灌注特征  

Enhancement patterns and perfusion parameters of breast invasive ductal cancer at contrast-enhanced ultrasound

作　　者：薛杰[1] 石磊[1] 曹小丽[1] 朱世光[2] 乔广东[2] 

机构地区：[1]青岛大学医学院附属烟台毓璜顶医院超声科,山东烟台264000 [2]青岛大学医学院附属烟台毓璜顶医院乳腺外科,山东烟台264000

出　　处：《医学影像学杂志》2013年第1期67-70,共4页Journal of Medical Imaging

基　　金：烟台市科技发展计划项目(No.2011226)

摘　　要：目的分析探讨乳腺癌的超声造影增强表现及血流灌注特征。方法对45例乳腺浸润性导管癌进行超声造影检查,分析比较肿瘤组织内部不同区域以及不同大小肿瘤的超声造影增强表现及血流灌注参数特征。结果 45例乳腺癌造影后43例(95.6%)肿瘤出现不同程度增强。其中25例(55.6%)不均匀增强,27例(60%)有血流灌注缺损,37例(82.2%)增强形态不规则,34例(75.6%)增强边界不清晰,32例(71.1%)有穿支血管,25例(55.6%)向心性增强。超声造影测值范围较常规超声增大。肿瘤组织比周围正常乳腺组织上升时间、达峰时间缩短,达峰强度增高,流入增大(P<0.05);肿瘤边缘与肿瘤中心区域相比,达峰时间缩短,达峰强度增高,流入斜率增大(P<0.05)。直径≤2.0cm和直径>2.0cm两组乳腺癌相应的血流灌注参数比较无显著差异(P>0.05)。结论超声造影不仅可以反映乳腺癌的形态学特征,还可以定量评价肿瘤的微循环灌注情况。Objective To investigate the enhancement patterns and blood perfusion parameters of contrast-enhanced ultrasound （CEUS） in breast cancer. Methods 45 patients with breast invasive ductal cancer were performed and analyzed using CEUS, enhancement patterns and blood perfusion parameters in different regions and different sizes of breast tumors was evaluated. Results For 2 cases without contrast agent perfusion in CEUS imaging, blood perfusion was observed in 43 cases. The 45 malignancies displayed heterogeneous enhancement in 25 cases （55.6 %）, local blood perfusion defect in 27 cases （60%）, irregular shape in 37 cases （82.2%）, poorly-defined margin in 34 cases （75.6%）, penetrating or tortuous surrounding vessels in 32 cases （71.1 % ）, centripetal enhancement in 25 cases （55.6 %）. The tumor sizes measured by CEUS were larger than those measured by ultrasound. In CEUS time intensity curve analysis, compared to that of the normal breast tissue, the RT and TTP seem faster, the PI and WIS seem higher in tumor tissues （ P 〈0.05）. Compared to that of the inside region of the tumor, TTP seem to be faster, PI and WIS seem higher in tumor periphery region （ P〈0.05）. However, blood perfusion parameters were no statistical differences in the 2 groups （≤2 cm in diameter and〉2 cm） （ P〉0.05）. Conclusion CEUS evaluate not only the morphologic features of the breast cancer, but also evaluate quantitatively the degree of blood perfusion in tumors.

关 键 词：乳腺肿瘤 超声检查 造影剂 

分 类 号：R737.9[医药卫生—肿瘤] R445.1[医药卫生—临床医学]