食管鳞状细胞癌中Survivin与Smac蛋白的表达及临床意义  

Expression and clinical significance of Survivin and Smac in esophageal squamous cell carcinoma

作　　者：李世森[1] 秦思达[1] 王希方[1] 许崇文[1] 李硕[1] 张伯翔[1] 孙良璋[1] 任宏[1] 

机构地区：[1]西安交通大学第一附属医院肿瘤外科,陕西西安710061

出　　处：《现代肿瘤医学》2013年第1期75-78,共4页Journal of Modern Oncology

基　　金：国家自然科学基金资助项目(编号:30740022);陕西省攻关项目资助(编号:2010K01-133)

摘　　要：目的:研究Survivin和Smac蛋白在食管鳞状细胞癌组织及其对应正常组织中的表达情况,以及与临床生物学指标的关系。方法:运用Western blot检测Survivin和Smac在42例食管鳞癌患者标本中的表达量,分析蛋白表达与患者临床资料的关系。结果:Survivin在食管鳞癌中的表达较正常组织高(t=25.733,P<0.05),Smac在癌旁正常组织的表达高于食管癌组织(t=7.510,P<0.05),且都有显著性差异。二者在肿瘤组织中的含量与肿瘤分化程度及淋巴结转移有关(P<0.05)。Survivin和Smac蛋白在肿瘤组织中表达呈负相关(r=-0.407,P=0.008)。结论:Survivin和Smac蛋白在食管鳞癌组织中表达异常,提示两者参与了食管鳞癌的发生发展和肿瘤转移。Objective：To investigate the expression of Survivin and Smac proteins in esophageal squamous cell carcinoma （ESCC） tissue and their relationship to the clinical and biological data. Methods： Expressions of Survivin and Smac proteins were detected by Western blot in 42 cases of ESCC. Results： The expression of Survivin in esopha- geal squamous cell carcinoma was significantly higher than in normal tissues （ t = 25. 733, P 〈 0. 05）, while the ex- pression of Smac in the adjacent normal tissues was significantly higher than in esophageal carcinoma （t = 7. 510 ,P 〈 0.05 ）. Both of two genes had correlation with tumor differentiation and lymph node metastasis （P 〈 0.05 ）. In addi- tion, Survivin had negative coralation with Smac in ESCC （ r = - 0. 407, P = 0. 008 ）. Conclusion： Abnormal expres- sion of Survivin and Smac occured in ESCC suggests that Survivin and Smac play an important role in the development and metastasis of ESCC.

关 键 词：SURVIVIN SMAC 食管鳞癌 WESTERN BLOT 

分 类 号：R735.1[医药卫生—肿瘤]