颈椎上皮样恶性外周神经鞘膜瘤的诊断  

Epitheloid malignant peripheral nerve sheath tumor:A case report and review of literatures

作　　者：高福平[1] 魏谨[1] 夏莉花[1] 秦冬梅[1] 孙琼[1] 

机构地区：[1]高淳县人民医院病理科,江苏高淳211300

出　　处：《现代肿瘤医学》2013年第1期186-187,共2页Journal of Modern Oncology

摘　　要：目的:探讨上皮样恶性外周神经鞘膜瘤(epitheloid malignant peripheral nerve sheath tumor,EMPNST)的临床病理学特征。方法:对1例上皮样恶性外周神经鞘膜瘤进行大体、组织病理学和免疫组化染色观察,并复习相关文献。结果:患者女性,49岁,病变发生于颈椎。镜下肿瘤细胞密集区与细胞稀疏区交替排列。免疫组化Vimentin(+++),S-100(+++),CgA(++),CD34(++),CK(-),EMA(-),HMB45(-),Actin(-),Desmin(-),Ki-67约10%阳性。结论:上皮样恶性外周神经鞘膜瘤是一种罕见的恶性软组织肿瘤,结合临床病理学特征及免疫组化,可作出正确诊断。Objective：To investigate the clinical and pathological features of epitheloid malignant peripheral nerve sheath tumor （EMPNST）. Methods： The clinical data were retrospectively analyzed of one case of ERMS. His- topathological and immunohistochemical changes of the tumor were also observed in the paraffin - embedded tissue samples. Results： The patient was a female, aged 49. The tumor located at cervical. Ly,it was positive for Vimentin , S - 100, CgA and CD34, negative for CK, EMA, HMB45, Actin, Desmin. Conclusion： EMPNST is a high grade malignant soft tissue neoplasm. And it is rarely to be found. Careful analysis of the clinico- pathological features and immunohistochemisitry will be helpful to an accurate diagnosis.

关 键 词：上皮样 恶性外周神经鞘膜瘤 病理诊断 免疫组化 鉴别诊断 

分 类 号：R730.264[医药卫生—肿瘤]