低剂量^(99m)Tc-MIBI乳腺断层双时相显像诊断乳腺癌的临床研究  

Clinical value of low dose ^(99m)Tc-MIBI double phase tomographic imaging in diagnosis of breast cancer

作　　者：文美玲[1] 梁庆模[1] 包铮[1] 赵小艳[1] 郑自贵[1] 

机构地区：[1]南华大学附属南华医院肿瘤内科,湖南省衡阳市421002

出　　处：《中国肿瘤临床》2013年第1期36-40,共5页Chinese Journal of Clinical Oncology

基　　金：湖南省卫生厅资助项目(编号:06SK3057)资助~~

摘　　要：目的:探讨低剂量99mTc-甲氧基异丁基异腈(MIBI)半定量分析在乳腺断层双时相显像诊断乳腺癌中的临床意义。方法:109例乳房肿块患者和26例正常对照者为临床研究对象,使用自制乳腺显像装置进行早期和延迟图像采集,图像行半定量分析(SQA),并与病理检查结果对照。结果:正常对照组、良性病变组、乳腺癌组的早期相T/NT比值分别为1.09±0.18、1.77±1.36、3.98±3.11,3组比较,差异有统计学意义(P<0.05)。正常对照组的早期相与延迟相T/NT比值差异无统计学意义[(1.09±0.18)vs.(1.08±0.19),P>0.05];良性病变组下降,差异有统计学意义[(1.77±1.36)vs.(1.28±0.83),P<0.05];乳腺癌组下降不明显,差异无统计学意义[(3.98±3.11)vs.(3.04±2.46),P>0.05]。半定量分析诊断乳腺癌的灵敏度为97.67%(42/43),特异性为81.82%(54/66),准确性为88.07%(96/109),阳性预测值为77.78%(42/54),阴性预测值为98.18%(54/55)。结论:低剂量99mTc-MIBI乳腺断层双时相显像是诊断乳腺癌的一种行之有效的方法,对鉴别乳腺良恶性病变有很好的临床应用价值。Objective： This study aims to investigate the clinical significance of the semi-quantitative analysis of low-dose ^99mTc-methoxy isobutyl isonitrile （MIBI） double phase tomographic imaging in breast cancer diagnosis. Methods： A total of 109 patients with breast lesions and 26 normal breasts underwent double-phase ^99mTc-MIBI tomographic imaging using a self-designed imaging device. The early and the delayed tumor to non-tumor ratios （T/NT） were calculated by semi-quantitative image analysis （SQA）. The results were compared with that of the pathological results. Results： The early phase T/NT ratios in the normal control, benign, and breast cancer groups were 1.09±0.18, 1.77±1.36, and 3.98±3.11, respectively. The difference was statistically significant （P〈0.05）. The difference of the early and delayed phase T/NT ratios in the normal control group was not statistically significant （1.09±0. 18 vs. 1.08±0.19, 〉0.05）. The difference in the benign group was statistically significant （1.77±1.36 vs. 1.28±0.83, P〈0.05）, whereas that of the breast cancer group was not statistically significant （3.98±3.11 vs. 3.04±2.46, P〉0.05）. The sensitivity of the semi-quantitative analysis in the diagnosis of breast cancer was 97.67%, the specificity was 81.82%, and the accuracy was 88.07%. The positive and negative values were 77.78% （42/54） and 98.18% （54/55）, respectively. Conclusion： Low dose ^99mTc-MIBI double-phase tomography imaging is an effective method to detect breast cancer, and has great clinical value in the differentiation of malignant and benign breast lesions.

关 键 词：乳腺肿瘤 低剂量99mTc-MIBI 半定量分析 

分 类 号：R737.9[医药卫生—肿瘤]