参芪杀白颗粒佐治小儿急性淋巴细胞白血病的临床研究  

Clinical Research of Shenqishabai Granule Combined with National Chemotherapy Ccheme on Children Acute Lymphoblastic Leukemia

作　　者：马玉红[1] 杨淑莲[1] 张广舫[1] 王东侠[1] 刘雪露[1] 马艳辉[1] 张文艺[1] 翁志国 王艳艳[1] 

机构地区：[1]河北省廊坊市中医医院,河北廊坊065000

出　　处：《中国中医急症》2013年第1期53-54,共2页Journal of Emergency in Traditional Chinese Medicine

摘　　要：目的比较参芪杀白颗粒联合全国化疗方案和单纯全国化疗方案治疗儿童急性淋巴细胞白血病(ALL)的临床疗效。方法将患儿分为两组,观察组采用参芪杀白颗粒联合全国化疗方案治疗,对照组单纯应用全国化疗方案治疗,观察两组诱导化疗结束缓解率、早期加强前和停药前微小残留病、化疗中感染情况、长期生存率等指标。结果观察组与对照组首次诱导缓解率和早期加强前的MRD检测结果无显著差异,观察组3年无病生存率较对照组提高,因病例数少,未显示出统计学意义。对82例3年无病生存患儿于停药前检查微小残留病,观察组阴性率明显高于对照组,感染率观察组较对照组明显降低。结论参芪杀白颗粒联合全国化疗方案治疗儿童ALL可起到增效减毒,提高机体的抗病能力,减少感染,清除体内微小残留病等作用,从而达到长期无病生存。Objective： To compare the clinical effect between Shenqishabai Granule combined with national chemotherapy scheme and mere national chemotherapy scheme. Methods： Patients were divided into two groups. Experimental group were treated with Shenqishabai Granule combined with national chemotherapy scheme,and control group were treated with national chemotherapy scheme merely. Then the remission rate of induction chemotherapy,micro-residual disease before early reinforcement and drug withdrawal,infection in chemotherapy, long time survival rate in two groups were observed. Results： The remission rate of first induction and micro- residual disease before early reinforcement in two groups were not statistically different. The disease free survival rate in experimental group was higher than that in control group, but there were no statistical differences because of the limited number. Micro-residual disease of the 82 patients were detected, who were survived three year for on disease before drug withdrawal. The negative rate in experimental group was extremely higher than that in control group. Additionally ,the infection rate in experimental group was extremely lower than that in control group. Conclusion： Shenqishabai Granule combined with national chemotherapy scheme on children ALL could increase the effect, decrease the toxicity, improve immunity, reduce infection and remove micro-residual disease. Finally patients could survive long time with no disease.

关 键 词：参芪杀白颗粒 儿童急性淋巴细胞 白血病 微小残留病 感染率 

分 类 号：R730.59[医药卫生—肿瘤]