2702例孕妇中期胎儿唐氏征筛查结果的分析  

Screening Analysis of Down's Syndromes in 2702 cases on Middle Period Pregnancy

作　　者：江先雨[1] 刘志伟 叶飞娣[1] 

机构地区：[1]深圳市第三人民医院,广东深圳518000 [2]深圳市罗湖区妇幼保健院,广东深圳518019

出　　处：《中国医药指南》2012年第36期264-265,共2页Guide of China Medicine

摘　　要：目的分析2702例孕妇中期胎儿唐氏征筛查结果,探讨孕妇中期胎儿唐氏征产前筛查的临床意义。方法采用贝克曼库尔特全自动化学发光酶免分析仪及原装试剂,对孕14～20+6周的孕妇血清进行甲胎蛋白(AFP)、人绒毛膜促性激素β亚基(β-HCG)及游离雌三醇(uE3)检测,并将孕妇的相关信息和检测的AFP、β-HCG、uE3结果输入"腾程筛查软件"中,进行三联检测的结果运算,得出一个概率指标。结果唐氏综合征(DS)筛查结果高危例数有65例,总阳性率为2.41%;其中:20～24岁年龄组的孕妇唐氏综合征筛查结果高危例数有11例(1.76%)25-29岁年龄组的孕妇唐氏综合征筛查结果高危例数有26例(1.93%);30-35岁年龄组的孕妇唐氏综合征筛查结果高危例数有9例(2.77%);>35岁年龄组的孕妇唐氏综合征筛查结果高危例数有19例(4.73%)。结论在中期孕妇进行唐氏综合征三联筛查是必要的,能够提高唐氏患儿的早期发现和诊断,是降低唐氏患儿出生率的有效方法。Objective To discussed the middle for pregnant women fetal down the clinical significance of prenatal screening,2702 cases were analyzed for pregnant women fetus down the middle screening results.Methods Used the Beckman Kurt automatic chemiluminescence enzyme from analyzer and original reagent to detection of AFP,β-HCG and uE3 content in pregnant women of 14～20＋6weeks.Pregnant women＇s information andAFP,β-HCG and uE3 assessment input ＂Tengcheng software＂ for joint screening,get a probability index.Results Down syndrome（DS） screening high-risk number results 65 cases,the total prevalence rate was 2.41%;Among them： 20～24 years old age group of pregnant women down＇s syndrome screening results have high-risk number 11 cases（1.76%）;25～29 age group of pregnant women down＇s syndrome screening results high-risk number 26 cases（1.93%）;30～35 years old age group of pregnant women down＇s syndrome screening high-risk number results 9 cases（2.77%）;35years old age group of pregnant women down＇s syndrome screening high-risk number results in 19 cases（1.73%）.Conclusion In the middle of pregnant women to press down＇s syndrome screening is necessary,to improve the children and early detection of Down＇s syndrome diagnosis,is to reduce the effective method to children with down＇s birth rate.

关 键 词：中期妊娠 唐氏综合征 产前筛查 

分 类 号：R715[医药卫生—妇产科学]